Table 3.
Comparisons of relative fluorescence intensity (RFI) values or percentages positive beads for each marker in the CD3(+) and CD3(–) fractions *
| CD3+ | CD3– | P‐values | ||||
|---|---|---|---|---|---|---|
| Marker | RFI | % | RFI | % | RFI | % |
| COX‐2 | 1·3 ± 0·4 | 13 ± 10·8 | 1·2 ± 0·2 | 11 ± 7 | 0·96 | 0·8 |
| OX40 | 1·8 ± 0·8 | 45 ± 28 | 1·6 ± 0·9 | 28 ± 17 | 0·35 | 0·03 |
| OX40L | 2·2 ± 0·7 | 44 ± 18 | 2·7 ± 1·3 | 56 ± 20 | 0·047 | 0·029 |
| CTLA‐4 | 0·9 ± 0·3 | 14 ± 19 | 1·3 ± 0·7 | 12 ± 15 | 0·047 | 0·79 |
| CD15s | 3·1 ± 2 | 47 ± 27 | – | – | – | – |
| CD44v3 | – | – | 1·9 ± 0·9 | 29 ± 25 | – | – |
| PD‐L1 | 1·6 ± 1 | 29 ± 30 | 1·8 ± 2 | 27 ± 26 | 0·79 | 0·89 |
| PD‐1 | 3·8 ± 2·7 | 92·7 ± 7·8 | 1·6 ± 0·6 | 47 ± 17 | 0·015 | < 0·0001 |
*The data are means ± standard error of the mean. The P‐values indicate differences in each marker expression levels in exosomes bound on beads [relative fluorescence intensity (RFI) or %]. COX‐2 = cyclo‐oxygenase 2; CTLA‐4 = cytotoxic T lymphocyte antigen‐4; PD‐L1 = programmed death ligand 2. Bold numbers indicate significant difference.