Table 2.
Dexmedetomidine plasma concentration, analogue‐to‐digital converter (ADC) unit and haemodynamic values during and after dexmedetomidine infusion
| Dexmedetomidine infusion | Post infusion | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 min | 1 min | 2 min | 3 min | 4 min | 5 min | 7.5 min | 10 min | 15 min | 15 min | 30 min | 60 min |
| Dexmedetomidine plasma concentration (ng ml –1 ) | |||||||||||
| 0 | 0.39 (0.26) | 1.11 (0.37) | 0.63 (0.17) | 0.52 (0.12) | 0.48 (0.13) | 0.44 (0.11) | 0.41 (0.09) | 0.43 (0.13) | 0.16 (0.04) | 0.12 (0.02) | 0.09 (0.02) |
| ADC units (% change from baseline) | |||||||||||
| 0 | 0 (3) | 22 (13) | 31 (15) | 29 (15) | 27 (15) | 25 (14) | 23 (14) | 23 (14) | 12 (9) | 9 (8) | 8 (6) |
| SBP (mmHg) | |||||||||||
| 125 (10) | 118 (10) | 114 (12) | 109 (12)* | 103 (14)* | 105 (13)* | 108 (13)* | |||||
| DBP (mmHg) | |||||||||||
| 65 (9) | 59 (11) | 61 (9) | 57 (10) | 55 (10) | 55 (10) | 58 (10) | |||||
| HR (bpm) | |||||||||||
| 67 (11) | 64 (8) | 67 (13) | 64 (11) | 65 (10) | 64 (11) | 63 (12) | |||||
Data are presented as mean (standard deviation). DBP, diastolic blood pressure; HR. heart rate; SBP, systolic blood pressure
*
Haemodynamic values that are significantly different from baseline (0 min) values (analysis of variance with Dunnett's post hoc test)