Table 3A.
Pharmacokinetic parameter estimates for the three‐compartment disposition model
| Parameter | Estimate | PPV | SE% | Shrinkage% | Bootstrap estimate | 95% CI |
|---|---|---|---|---|---|---|
| CL (l min –1 70 kg –1 ) | 0.751 | 0.158 | 4.6 | 5.7 | 0.712 | 0.107, 0.872 |
| Q2 (l min –1 70 kg –1 ) | 1.01 | 0.590 | 11.2 | 9.4 | 0.96 | 0.531, 1.816 |
| Q3 (l min –1 70 kg –1 ) | 1.03 | 3.7 | 1.06 | 0.674, 1.39 | ||
| V1 (l 70 kg –1 ) | 12 | 0.339 | 6.3 | 4.6 | 12.8 | 9.570, 16.9 |
| V2 (l 70 kg –1 ) | 11.7 | 0.868 | 13.1 | 5.9 | 13.1 | 6.369, 35.61 |
| V3 (l 70 kg –1 ) | 47.2 | 11.2 | 48.4 | 35.295, 217.025 | ||
| ERR ADD (μg l −1 ) | 0.011 | ηRUV 0.66 |
5.4 |
0.010 | 0.001, 0.132 | |
| ERR PROP (%) | 10.4 | 11.8 | 7.02, 19.36 |
ηRUV, variance of the residual unidentified variability; CI, confidence interval; CL, clearance; ERRADD, additive residual error; ERRPROP, proportional residual error; PPV, apparent coefficient of variation of between‐subject variability, estimated using an exponential random‐effect model [sqrt(NONMEM Omega)]; Q2 and Q3, intercompartment clearances; SE, standard error of the structural parameter estimate; V1, central volume; V2 and V3, peripheral volumes