Table 4A.
Parameter estimates for an effect compartment concentration–response relationship using an EMAX model (BSV is the between subject parameter variability, CI is the confidence interval presented as 5th, 95th)
| Parameter | Estimate | PPV | Shrinkage% | Bootstrap estimate | 95% CI |
|---|---|---|---|---|---|
| E 0 (ADC units) | 5860 | 0.462 | 11.3 | 5666 | 4549, 7527 |
| E MAX (ADC units) | 3090 | 1.349 | 13 | 3160 | 1540, 7777 |
| C 50 (μg l −1 ) | 0.233 | 1.628 | 28.6 | 0.211 | 0.098, 0.390 |
| Hill coefficient | 2.83 | 3.28 | 1.70, 4.35 | ||
| t 1/2 keo (min) | 2.16 | 0.841 | 18.2 | 2.01 | 1.37, 2.90 |
| ERRADD (ADC units) | 113 | ηRUV 0.442 |
29.2 |
103 | 72, 138 |
| ERRPROP (%) | 61.8 | 61.8 | 36.4, 326 |
ηRUV, variance of the residual unidentified variability; C50, concentration in the effect compartment producing 50% of EMAX; CI, confidence interval; EMAX, maximum response for vasoconstriction; E0, baseline effect; ERRADD, additive residual error; ERRPROP, proportional residual error; t½ keo, half‐life for equilibration; PPV, apparent coefficient of variation of between‐subject variability, estimated using an exponential random‐effect model [sqrt(NONMEM Omega)]