Table 3.
Summary of the tested covariate effects on OBJs
| Tested covariates | ΔOBJ (1st selection) a | ΔOBJ (2nd selection) | ΔOBJ (3rd selection) |
|---|---|---|---|
| Effect on CL R /F | |||
| ABCB1 1236 T/T | −2.72 | ||
| ABCG2 421A/A | −3.93 | −4.24 | 1.17 |
| CYP3A5*3 | −3.73 | ||
| Amiodarone | −b | ||
| Effect on CL NR /F | |||
| ABCB1 1236 T/T | −4.82 | −3.31 | |
| ABCG2 421A/A | −8.99 | −6.80 | Included |
| CYP3A5*3 | −9.12 | Included | Included |
| Amiodarone | −7.09 | −b | |
| Effect on Vd/F | |||
| BW with Eq. (8) | 0.01 | ||
| BW with Eq. (9) | 1.96 |
a
The difference from the OBJ value was calculated using the covariate model including Ccr with Eq. (6) (OBJ value, 2625.89), and it is expressed to two decimal places.
b
Calculation of the OBJ value was not conducted.