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. 2018 Jan 3;175(12):2204–2218. doi: 10.1111/bph.14089

Figure 5.

Figure 5

Diminazene (DA) has potent but heterogeneous antihyperalgesic activity in the FCA rat model of unilateral inflammatory pain. Rats were classified as responders/high responders (A, C, E) or non‐responders/low responders (B, D, F) based on examination of ΔPPT AUC values for the individual ipsilateral hindpaws. ΔPPT AUC values of responders given morphine (Mor) at 700 nmol (n = 17) or diminazene at 5.8 nmol (n = 8), 19.4 nmol (n = 6), 58.2 nmol (n = 4), 194 nmol (n = 7) and 582 nmol (n = 6) were significantly higher than the corresponding ΔPPT AUC values evoked by vehicle (n = 15) (*P < 0.05 one‐way ANOVA). Diminazene at 1.9 nmol (n = 5) was not significantly different from vehicle. There was no significant difference between ΔPPT AUC values of non‐responders/low responders given morphine (n = 10) or diminazene at 1.9 nmol (n = 10), 5.8 nmol (n = 5), 19.4 nmol (n = 10), 58.2 nmol (n = 13), 194 nmol (n = 9) and 582 nmol (n = 8) when compared to the ΔPPT AUC of vehicle. The dotted line in (A) indicates the PPT from the contralateral hindpaw.