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. 2018 Jan 3;175(12):2204–2218. doi: 10.1111/bph.14089

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APETx2 has potent partial and heterogeneous antihyperalgesic activity in the FCA rat model of unilateral inflammatory pain. Rats were classified as responders/high responders (A, C, E) or non‐responders/low responders (B, D, F) based on examination of ΔPPT AUC values for the individual ipsilateral hindpaws. The ΔPPT AUC values of responders given morphine (Mor) at 700 nmol (n = 13) or APETx2 at 0.1 pmol (n = 6) and 1.1 pmol (n = 9) were significantly higher than the corresponding ΔPPT AUC values evoked by vehicle (n = 10). *P < 0.05, one‐way ANOVA. APETx2 at 0.03 pmol (n = 6), 3.3 pmol (n = 8) and at 11 pmol (n = 6) were not significantly different from vehicle. The dotted line in (A) indicates the PPT from the contralateral hindpaw.