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. 2018 Jan 3;175(12):2204–2218. doi: 10.1111/bph.14089

Figure 7.

Figure 7

APETx2 potentiates the response of rASIC1b and rASIC2a (when applied during the conditioning pH) but not that of rASIC1a, expressed in Xenopus oocytes. (A) Traces showing the minor inhibitory effect on rASIC1a but rapid and reversible potentiating effect of APETx2 (10 μM) on rat ASIC1b and ASIC2a. (B) Traces showing the concentration‐dependent effect of APETx2 on ASIC1b and ASIC2a. (C) Concentration–response curves of APETx2 on homomeric rat ASIC1a (n = 5), ASIC1b (n = 5), ASIC2a (n = 5) and ASIC3 (n = 6). Curves were fitted using the log[inhibitor] versus normalized response equation in GraphPad 7.0. (D) Quantification of the effect of APETx2 on the activation and desensitization of rASIC1b (n = 5) and rASIC2a (n = 7) whole‐cell currents recorded from Xenopus oocytes [presented as rise and decay times (10–90%)], *P < 0.05, significantly different from control; paired t‐test.