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. 2017 Jul 30;175(12):2261–2271. doi: 10.1111/bph.13935

Figure 4.

Figure 4

Carbamazepine reduces the firing of DRG sensory neurons expressing Nav1.7‐I234T mutant channels. (A–F) Heatmap of a representative MEA recording of DRG sensory neurons expressing Nav1.7‐I234T with DMSO or carbamazepine (CBZ) pre‐incubation. Carbamazepine produces a pronounced reduction in the number of active electrodes and mean firing frequency. (G) mean firing frequency of neurons expressing Nav1.7‐I234T channels with DMSO or carbamazepine pre‐incubation at all three temperatures (33, 37 and 40°C). *P <0.05, significantly different from DMSO; n = 6 experiments with 12 rats. (H) Averaged number of active electrodes from neurons expressing Nav1.7‐I234T channels with DMSO or carbamazepine pre‐incubation at all three temperatures (33, 37 and 40°C). *P <0.05, significantly different from DMSO.