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. 2017 Jul 30;175(12):2261–2271. doi: 10.1111/bph.13935

Figure 5.

Figure 5

Carbamazepine does not reduce the firing of DRG sensory neurons expressing Nav1.7‐WT channels significantly. (A–F) Heatmap of a representative MEA recording of DRG sensory neurons expressing Nav1.7‐WT channels with DMSO or carbamazepine (CBZ) pre‐incubation. Carbamazepine did not significantly affect the firing frequency of these neurons. (G) Mean firing frequency of neurons expressing Nav1.7‐WT channels with pre‐incubation with DMSO or carbamazepine, at all three temperatures (33, 37 and 40°C). n = 5 experiments with 10 rats. (H) Averaged number of active electrodes from neurons expressing Nav1.7‐WT channels with DMSO or carbamazepine pre‐incubation at all three temperatures (33, 37 and 40°C).