Table 1.
Demographic and clinical characteristics among study participants across three different datasets
| Database | Three LHID combined | |||||
|---|---|---|---|---|---|---|
| Characteristic | Controls | AF | ORa | 95% CI | ||
| (n = 28 529) | (n = 28 529) | |||||
| Demographic characteristics | ||||||
| Age (years; n, %) | ||||||
| 45–54 | 2142 | (7.51) | 2142 | (7.51) | N/A | N/A |
| 55–64 | 4631 | (16.23) | 4631 | (16.23) | ||
| 65–74 | 7362 | (25.81) | 7362 | (25.81) | ||
| ≥75 | 14 394 | (50.45) | 14 394 | (50.45) | ||
| Gender (n, %) | ||||||
| Male | 15 595 | (54.66) | 15 595 | (54.66) | N/A | N/A |
| Female | 12 934 | (45.34) | 12 934 | (45.34) | ||
| Clinical characteristics: comorbidities | ||||||
| T2DM | 6815 | (23.89) | 6815 | (23.89) | N/A | N/A |
| CKD | 2528 | (8.86) | 3669 | (12.86) | 1.56 | 1.47–1.65 |
| Hypertension | 17 183 | (60.23) | 17 183 | (60.23) | N/A | N/A |
| MI | 500 | (1.75) | 981 | (3.44) | 2.02 | 1.81–2.25 |
| CHF | 9353 | (32.78) | 9353 | (32.78) | N/A | N/A |
| Sleep apnoea | 4331 | (15.18) | 4704 | (16.49) | 1.11 | 1.06–1.16 |
| Hyperthyroidism | 146 | (0.51) | 277 | (0.97) | 1.90 | 1.56–2.33 |
| AS | 67 | (0.23) | 71 | (0.25) | 1.06 | 0.76–1.48 |
| SLE | 29 | (0.10) | 30 | (0.11) | 1.03 | 0.62–1.72 |
| RA | 273 | (0.96) | 341 | (1.20) | 1.26 | 1.07–1.47 |
| Osteoarthritis | 7012 | (24.58) | 7012 | (24.58) | N/A | N/A |
| Gout | 2784 | (9.76) | 3311 | (11.61) | 1.22 | 1.16–1.29 |
| CAD | 5676 | (19.90) | 9147 | (32.06) | 2.05 | 1.96–2.13 |
| VHD | 890 | (3.12) | 2081 | (7.29) | 2.53 | 2.32–2.74 |
| Concomitant medication use | ||||||
| Antidepressants | 2811 | (9.85) | 3391 | (11.89) | 1.24 | 1.18–1.31 |
| Anticonvulsants | 2562 | (8.98) | 3287 | (11.52) | 1.32 | 1.25–1.40 |
| Anxiolytics | 10 506 | (36.83) | 12 735 | (44.64) | 1.41 | 1.36–1.46 |
| Benzodiazepines | 4822 | (16.90) | 6020 | (21.10) | 1.33 | 1.27–1.39 |
| Bisphosphonates | 67 | (0.23) | 72 | (0.25) | 1.08 | 0.77–1.50 |
| Glucocorticosteroids | 4142 | (14.52) | 5106 | (17.90) | 1.29 | 1.23–1.35 |
| HRT | 606 | (2.12) | 700 | (2.45) | 1.17 | 1.04–1.31 |
a
Conditional logistic regression was used to compute odds ratio and 95% confidence interval.
AF, atrial fibrillation; AS, ankylosing spondylitis; CAD, coronary artery disease; CHF, congestive heart failure; CKD, chronic kidney disease; HRT, hormone replacement therapy; LHID, Longitudinal Health Insurance Database; MI, myocardial infarction; OR, odds ratio; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; T2DM, type 2 diabetes mellitus; VHD, valvular heart disease.