Table 2.
Association between NSAID use and atrial fibrillation, based on various NSAID exposure statuses
| Controls | AF | Total | COR | 95% CI | AORa | 95% CI | |
|---|---|---|---|---|---|---|---|
| LHID2000 | |||||||
| Non‐users | 3351 (31.29) | 2836 (26.48) | 6187 | ||||
| Users | 7357 (68.71) | 7872 (73.52) | 15 229 | 1.29 | 1.22–1.38 | 1.15 | 1.08–1.23 |
| New users | 198 (1.85) | 399 (3.73) | 597 | 2.40 | 2.01–2.87 | 2.28 | 1.89–2.74 |
| Continuous users | 2045 (19.10) | 2718 (25.38) | 4763 | 1.64 | 1.52–1.78 | 1.42 | 1.30–1.55 |
| Past users | 5114 (47.76) | 4755 (44.41) | 9869 | 1.12 | 1.05–1.20 | 1.02 | 0.95–1.09 |
| Total | 10 708 | 10 708 | 21 416 | ||||
| LHID2005 | |||||||
| Non‐users | 3534 (32.11) | 2938 (26.69) | 6472 | ||||
| Users | 7473 (67.89) | 8069 (73.31) | 15 542 | 1.34 | 1.26–1.42 | 1.20 | 1.13–1.29 |
| New users | 244 (2.22) | 407 (3.70) | 651 | 2.04 | 1.72–2.41 | 1.99 | 1.67–2.36 |
| Continuous users | 2071 (18.82) | 2728 (24.78) | 4799 | 1.66 | 1.53–1.80 | 1.45 | 1.33–1.58 |
| Past users | 5158 (46.86) | 4934 (44.83) | 10 092 | 1.19 | 1.11–1.27 | 1.08 | 1.01–1.16 |
| Total | 11 007 | 11 007 | 22 014 | ||||
| LHID2010 | |||||||
| Non‐users | 2826 (31.74) | 2367 (26.58) | 5193 | ||||
| Users | 6078 (68.26) | 6537 (73.42) | 12 615 | 1.31 | 1.23–1.40 | 1.18 | 1.10–1.27 |
| New users | 175 (1.97) | 313 (3.52) | 488 | 2.15 | 1.77–2.61 | 2.14 | 1.75–2.61 |
| Continuous users | 1721 (19.33) | 2303 (25.86) | 4024 | 1.66 | 1.52–1.82 | 1.46 | 1.32–1.60 |
| Past users | 4182 (46.97) | 3921 (44.04) | 8103 | 1.14 | 1.06–1.23 | 1.04 | 0.96–1.12 |
| Total | 8904 | 8904 | 17 808 | ||||
| Three LHID combined | |||||||
| Non‐users | 9065 (31.77) | 7581 (26.57) | 16 646 | ||||
| Users | 19 464 (68.23) | 20 948 (73.43) | 40 412 | 1.32 | 1.27–1.37 | 1.18 | 1.14–1.23 |
| New users | 573 (2.01) | 1058 (3.71) | 1631 | 2.24 | 2.01–2.49 | 2.18 | 1.95–2.43 |
| Continuous users | 5441 (19.07) | 7188 (25.20) | 12 629 | 1.65 | 1.57–1.74 | 1.44 | 1.36–1.52 |
| Past users | 13 450 (47.15) | 12 702 (44.52) | 26 152 | 1.16 | 1.11–1.21 | 1.05 | 1.01–1.10 |
| Total | 28 529 | 28 529 | 57 058 | ||||
a
Adjusted variables included: medical comorbid disorders (CKD, MI, sleep apnoea, hyperthyroidism, ankylosing spondylitis, SLE, RA, gout, CAD and VHD), and concomitant medication use (antidepressants, anticonvulsants, anxiolytics, benzodiazepines, bisphosphonates, glucocorticosteroids and HRT).
AF, atrial fibrillation; AOR, adjusted odds ratio; CAD, coronary artery disease; CKD, chronic kidney disease; COR, crude odds ratio; HRT, hormone replacement therapy; LHID, Longitudinal Health Insurance Database; MI, myocardial infarction; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; VHD, valvular heart disease.