Table 2.
Comparison of activation and inactivation parameters between Cav2.2 and Cav3.1 channels before and after application of MONIRO‐1
| Cav2.2 | Cav3.1 | |||
|---|---|---|---|---|
| Control | MONIRO‐1 (30 μM)a | Control | MONIRO‐1 (3 μM)a | |
| τ activation | 1.81 ± 0.15 ms (5) | 1.51 ± 0.17 ms (5) | 1.90 ± 0.08 ms (5) | 3.45 ± 0.51 ms (5)* |
| τ inactivation | 61.75 ± 13.69 ms (5) | 44.45 ± 7.61 ms (5) | 10.78 ± 0.52 ms (5) | 17.91 ± 0.74 ms (5)* |
| V0.5 activation | 12.5 ± 0.5 mV (5) | 12.4 ± 0.4 mV (5) | −34.0 ± 0.4 mV (7) | −34.4 ± 0.6 mV (7) |
| V0.5 inactivation | −41.3 ± 0.7 mV (5) | −52.9 ± 1.3 mV (5)* | −53.5 ± 0.6 mV (6) | −55.1 ± 0.6 mV (6) |
| Slope factor | 5.3 ± 0.6 (5) | 10.2 ± 1.2 (5)* | 4.4 ± 0.6 (6) | 6.1 ± 0.5 (6) |
*
P < 0.05 compared with control, Students t‐test. Data presented as mean ± SEM and n is given in brackets.
a
Concentration chosen based on IC50 of individual channel.