Table 5.
Frequencies of missed drug–drug interactions in MEDUCATE database
| Severity score | Missed interactions | Total interactions in database |
|---|---|---|
| F (potentially life threatening) | ||
| RAAS inhibitors + potassium sparing diuretics | 6 | 45 |
| QT‐prolongation drug + QT‐prolongation drug | 4 | 5 |
| Potassium + potassium‐sparing diuretics | 1 | 5 |
| E (potential for permanent harm) | ||
| MTX + NSAID | 4 | 31 |
| Coumarin + miconazole | 3 | 3 |
| Trimethoprim + RAAS inhibitors/spironolactone | 2 | 6 |
| Simvastatin/atorvastatin + CYP3A4 inhibitors | 1 | 7 |
| SSRI + thiazide | 1 | 4 |
| Statin + colchicine | 1 | 11 |
| D (potential need for hospitalization) | ||
| RAAS inhibitors + diuretics | 22 | 103 |
| Diuretics + NSAID | 7 | 20 |
| RAAS inhibitors + NSAID | 5 | 25 |
| Coumarin + omeprazole | 5 | 25 |
| Coumarin + antibiotics | 5 | 11 |
| Coumarin + amiodarone/propafenone | 2 | 11 |
| MTX + antibiotics | 1 | 2 |
| Coumarin + vitamin K | 1 | 1 |
CYP3A4, cytochrome P450 3A4; NSAID, nonsteroidal anti‐inflammatory drug; MTX, methotrexate; RAAS, renin–angiotensin–aldosterone system; SSRI, selective serotonin reuptake inhibitor