Table 2.
Reports of vitamin D toxicity due to errors in formulation
| Author, year (reference) | Country | Stated dose | Actual dose received | Number of patients affected |
|---|---|---|---|---|
| Koutkia et al., 2001 27 | US | 2000 IU | 156 000–2.6 M IU day–1 | 1 adult |
| Klontz et al., 2007 28 | US | 400 IU | 188 000 | 1 adult +3 children |
| Kaptein et al., 2010 34 | Netherlands | 150 IU | 15 000–150 000 IU | 2 adults |
| Lowe et al., 2011 35 | Dominican Republic | 600 000 IU/5 ml | 900 000–1 M IU | 9 adults |
| Araki et al., 2011 21 | US | 1600 IU | 186 000 IU | 2 adults |
| Granado‐Lorencio et al., 2012 41 | Ecuador |
Unstated Vial day–1 for 4 weeks |
600 000 IU/vial | 1 adult |
| Kara et al, 2014 31 | Turkey | 2000 IU/5 ml | 800 000 IU | 7 children |
| Bell et al., 2013 42 | Australia | 300 IU day–1 | 300 000 IU | 1 adult |
| Anik et al., 2013 32 | Turkey | 10 IU ml–1 | Unknown | 3 children |
| Benemei et al., 2013 29 | Italy | 600 IU | 52 800 IU | 3 adults |
| Marins et al., 2014 43 | Brazil | 2000 day–1 | 4 M IU day–1 | 1 adult |
| Ketha et al., 2015 30 | US | 2000 IU/drop | 6000 IU/drop | 1 child |
| Zigenhorn et al., 2016 37 | Netherlands | 78× stated dose | 1 adult | |
| Guerra et al., 2016 36 | Brazil | 2000 IU | Unknown | 1 adult |