Figure 5.
Effects of Compound 6 (i.p.) on METH‐PPI disruption in mice with and without i.cb. pretreatment with furosemide. Compound 6 (3 or 10 mg·kg−1) or vehicle was administered by i.p. injection 10 min before injection of methamphetamine (2 mg·kg−1, i.p.). Furosemide was administered by i.cb. bilaterally alone or 5 min before Compound 6 (10 mg·kg−1, i.p.) was given. PPI was measured and analysed as in Figure 2. Data shown are means ± SEM; n = 8. * P < 0.05, significantly different from the control group, # P < 0.05, significantly different from the vehicle group, & P < 0.05, significantly different from the Compound 6 alone group.