Table 4.

mg-G × E (Continuous) Interaction Models for CMRFs

Trait	Environment/SNP	G × E Model vs. G × E Model with SNP
		Model	Ln Likelihood	LR Test	p-value*
BMI	HPFs	G × E	−243.601971
	rs1333049	mg-G × E	−234.296911	18.61012	1.6 × 10−05
	rs16986921	mg-G × E	−236.050597	15.102748	1.0 × 10−04
	rs12695382	mg-G × E	−234.814916	17.57411	2.8 × 10−05
	SA_y	G × E	−285.269841
	rs1333049	mg-G × E	−278.646201	13.24728	2.7 × 10−04
	rs16986921	mg-G × E	−281.860341	6.819	9.0 × 10−03
	rs12695382	mg-G × E	−280.859309	8.821064	3.0 × 10−03
WC	HPFs	G × E	−225.552263
	rs1333049	mg-G × E	−215.260173	20.58418	5.7 × 10−06
	rs16986921	mg-G × E	−217.893680	15.317166	9.9 × 10−05
	rs12695382	mg.G × E	−216.345399	9.206864	2.4 × 10−03
	SA_u	G × E	−272.055371
	rs1333049	mg-G × E	−264.180104	15.750534	7.2 × 10−05
	rs16986921	mg-G × E	−268.201910	7.706922	5.5 × 10−03
	rs12695382	mg-G × E	−266.696222	10.718298	1.1 × 10−03
	SA_y	G × E	−280.98437
	rs1333049	mg-G × E	−273.575208	14.818324	1.2 × 10−04
	rs16986921	mg-G × E	−276.766953	8.434834	3.7 × 10−03
	rs12695382	mg-G × E	−275.082909	11.802922	5.9 × 10−04
FM	HPFS	G × E	−254.258788
	rs1333049	mg-G × E	−245.938561	16.640454	4.5 × 10−05
	rs16986921	mg-G × E	−247.401557	13.714462	2.1 × 10−04
	rs12695382	mg-G × E	−247.328433	13.86071	2.0 × 10−04
	SA_y	G × E	−295.452938
	rs1333049	mg-G × E	−290.640463	9.624950	1.9 × 10−03
	rs16986921	mg-G × E	−292.985805	4.934266	2.6 × 10−02
	rs12695382	mg-G × E	−291.236897	8.432082	3.7 × 10−03
FI	SA_u	G × E	−284.342451
	rs1333049	mg-G × E	−280.948679	6.787544	9.2 × 10−03
	rs16986921	mg-G × E	−283.886050	0.912802	0.3393721a
	rs12695382	mg-G × E	−281.444604	5.795694	1.6 × 10−02
	SA_y	G × E	−284.684313
	rs1333049	mg-G × E	−281.619929	6.128768	1.3 × 10−02
	rs16986921	mg-G × E	−284.359511	0.649604	0.4202543a
	rs12695382	mg-G × E	−281.660447	6.047732	1.4 × 10−02
HOMA-IR	HPFs	G × E	−233.624161
	rs1333049	mg-G × E	−232.027806	3.19271	0.0739673a
	rs16986921	mg-G × E	−233.469271	0.30978	0.5778152a
	rs12695382	mg-G × E	−231.407711	4.43290	3.5 × 10−02
	SA_u	G × E	−283.079218
	rs1333049	mg-G × E	−280.748401	4.661634	3.1 × 10−02
	rs16986921	mg-G × E	−282.714627	0.729182	0.3931485a
	rs12695382	mg-G × E	−280.560791	5.036854	2.5 × 10−02
	SA_y	G × E	−285.138691
	rs1333049	mg-G × E	−282.592845	5.091692	2.4 × 10−02
	rs16986921	mg-G × E	−284.678495	0.920392	0.3373721a
	rs12695382	mg-G × E	−282.243916	5.789550	1.6 × 10−02
MSC	SA_u	G × E	−273.293816
	rs1333049	mg-G × E	−271.051664	4.484304	3.4 × 10−02
	rs16986921	mg-G × E	−271.921924	2.743784	0.0976333a
	rs12695382	mg-G × E	−272.280778	2.026076	0.1546194a
HDL	SA_y	G × E	−268.742515
	rs1333049	mg-G × E	−267.394514	2.696002	0.1006002a
	rs16986921	mg-G × E	−267.246377	2.992276	0.0836625a
	rs12695382	mg-G × E	−268.714120	0.056790	0.7723941a
DBP	SA_u	G × E	−294.771576
	rs1333049	mg-G × E	−287.273606	14.995940	1.1 × 10−04
	rs16986921	mg-G × E	−289.493242	10.556668	1.2 × 10−03
	rs12695382	mg-G × E	−291.119736	7.30368	6.9 × 10−03

LR = likelihood ratio;

^*Significant after multiple testing correction (FDR = 0.05) unless indicated by ^a