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Microscopic pictures of Hematoxylin and Eosin section from specimen harboring perineural (PNI) and intraneural invasion by squamous cell carcinoma. A: Large extra-tumoral 5 mm in diameter nerve with intraneural invasion by carcinoma (arrows). B: Small (<0.5 mm) nerve (n) with PNI partially wrapped by tumor (arrow). C: Several foci (>1) of intratumoral PNI in a single tumor section (n: nerve, arrow: tumor). D: Small (<0.5 mm) nerve (n) with PNI completely surrounded by tumor (arrow).
