. 2018 Mar 5;23(3):e12537. doi: 10.1111/anec.12537

Table 2.

Hazard ratios for factors associated with a first cardiac event (syncope, aborted cardiac arrest, or sudden cardiac death)

Risk factor	LQT1: Hazard ratio 95% confidence int. (p‐value)	LQT2: Hazard ratio 95% confidence int. (p‐value)	LQT3: Hazard ratio 95% confidence int. (p‐value)
Proband vs. family member	3.21 2.47–4.16 (p < .001)	2.48 1.91–3.22 (p < .001)	2.83 1.62–4.95 (p < .001)
QTc > 500 ms vs. <500 ms	1.90 1.44–2.50 (p < .001)	2.02 1.50–2.71 (p < .001)	1.93 1.05–3.52 (p = .033)
Male <age 14 years	2.15 1.59–2.90 (p < .001)	1.69 1.15–2.48 (p = .007)	0.54 0.23–1.28 (p = .161)
Female ≥age 14 years	1.76 1.08–2.84 (p = .023)	3.15 2.14–4.64 (p < .001)	1.68 0.85–3.31 (p = .137)
Beta‐blockers vs. no beta‐blockers	0.49 0.31–0.76 (p = .002)	0.48 0.31–0.74 (p = .001)	0.63^a 0.30–1.32 (p = .219)

Risk factor

LQT1: Hazard ratio 95% confidence int. (p‐value)

LQT2: Hazard ratio 95% confidence int. (p‐value)

LQT3: Hazard ratio 95% confidence int. (p‐value)

Proband vs. family member

3.21

2.47–4.16

(p < .001)

2.48

1.91–3.22

(p < .001)

2.83

1.62–4.95

(p < .001)

QTc > 500 ms vs. <500 ms

1.90

1.44–2.50

(p < .001)

2.02

1.50–2.71

(p < .001)

1.93

1.05–3.52

(p = .033)

Male <age 14 years

2.15

1.59–2.90

(p < .001)

1.69

1.15–2.48

(p = .007)

0.54

0.23–1.28

(p = .161)

Female ≥age 14 years

1.76

1.08–2.84

(p = .023)

3.15

2.14–4.64

(p < .001)

1.68

0.85–3.31

(p = .137)

Beta‐blockers vs. no beta‐blockers

0.49

0.31–0.76

(p = .002)

0.48

0.31–0.74

(p = .001)

0.63^a

0.30–1.32

(p = .219)

Hazard ratios were adjusted for decade of birth.

Number of cardiac events utilized in each genotype analysis: LQT1 = 303; LQT2 = 297; LQT3 = 69. Significant hazard ratios are highlighted in bold.

LQT3 gender‐specific effects were: females HR = 0.32, p = .078, males HR = 1.37, p = .611.