Table 4.
β-Coefficients and predicted mean hormone levelsa and 95% confidence intervals (95% CI) from regression modelsb for associations between serum thyroid hormone levelsc and urinary reproductive hormone concentrations among Michigan women without thyroid disease, 2004–2014
| Early follicular FSH (mIU/mg Cr) | Late luteal FSH (mIU/mg Cr) | Luteal phase maximum Pd3G (μg/mg Cr) | Mid-luteal Pd3G (μg/mg Cr) | Follicular phase maximum E13G (ng/mg Cr) | Luteal phase maximum E13G (ng/mg Cr) | Early follicular E13G (ng/mg Cr) | Preovulatory E13G (ng/mg Cr) | Mid-luteal E13G (ng/mg Cr) | |
|---|---|---|---|---|---|---|---|---|---|
| n=73 women | n=72 women | n=62 women | n=75 women | n=48 women | n=64 women | n=73 women | n=74 women | n=75 women | |
| n=186 cycles | n=186 cycles | n=137 cycles | n=207 cycles | n=90 cycles | n=136 cycles | n=220 cycles | n=202 cycles | n=207 cycles | |
| TSHd,e | |||||||||
| Low (vs. Medium) | +0.2 (−1.3, 1.7) | +0.0 (−1.4, 1.3) | − −0.2 (−1.3, 0.8) | −0.2 (−1.1, 0.7) | +1.0 (−5.0, 7.0) | −0.9 (−4.1, 2.4) | +0.2 (−0.8, 1.2) | +0.5 (−2.3, 3.3) | −0.4 (−2.4, 1.6) |
| Medium | 8.4 (6.4, 10.3) | 4.9 (3.1, 6.6) | 9.6 (8.2, 11.0) | 8.2 (7.1, 9.4) | 38.0 (32.7, 43.3) | 30.1 (25.7, 34.4) | 9.3 (8.0, 10.6) | 28.8 (25.2, 32.4) | 19.6 (17.0, 22.3) |
| High (vs. Medium) | −0.7 (−3.1, 1.7) | −0.4 (−2.6, 1.7) | +0.7 (−1.0, 2.4) | +0.6 (−0.8, 2.0) | −3.5 (−9.0, 2.0) | −0.3 (−5.5, 5.0) | −0.8 (−2.4, 0.8) | −2.2 (−6.5, 2.2) | −0.2 (−3.4, 2.9) |
| Total T4f | |||||||||
| Low (vs. Medium) | −0.8 (−3.5, 1.8) | −0.9 (−3.3, 1.4) | −1.4 (−3.2, 0.4) | −0.9 (−2.3, 0.6) | −0.6 (−6.8, 5.5) | −0.9 (−7.1, 5.2) | −0.5 (−2.2, 1.3) | −0.9 (−5.5, 3.6) | −0.3 (−3.7, 3.1) |
| Medium | 8.1 (6.0, 10.2) | 4.8 (2.9, 6.6) | 9.5 (8.1, 10.9) | 7.9 (6.7, 9.0) | 34.3 (29.4, 39.2) | 28.5 (23.9, 33.2) | 9.2 (7.8, 10.6) | 25.9 (22.2, 29.5) | 17.8 (15.1, 20.5) |
| High (vs. Medium) | +1.0 (−1.4, 3.3) | +0.7 (−1.3, 2.7) | +2.2 (0.7, 3.8) | +2.2 (1.0, 3.4) | +7.4 (2.3, 12.4) | +3.2 (−2.0, 8.4) | −0.1 (−1.7, 1.5) | +5.8 (1.9, 9.8) | +3.8 (0.9, 6.6) |
| Total T3g | |||||||||
| Low (vs. Medium) | +1.9 (−1.1, 4.8) | +1.6 (−1.1, 4.2) | −0.8 (−3.1, 1.5) | −1.0 (−2.8, 0.7) | −2.9 (−10.5, 4.7) | −4.0 (−11.1, 3.1) | −1.7 (−3.6, 0.3) | −4.3 (−9.6, 0.9) | −1.9 (−5.7, 1.9) |
| Medium | 7.5 (5.0, 10.0) | 4.3 (2.1, 6.5) | 9.8 (8.1, 11.5) | 8.4 (6.9, 9.8) | 35.5 (29.6, 41.5) | 28.7 (23.4, 34.0) | 9.4 (7.7, 11.0) | 26.8 (22.5, 31.2) | 17.8 (14.6, 20.9) |
| High (vs. Medium) | −0.1 (−3.8, 3.6) | −0.6 (−3.9, 2.8) | +1.0 (−1.6, 3.5) | +1.2 (−1.0, 3.4) | +9.2 (−1.5, 19.8) | +6.6 (−1.3, 14.5) | +0.7 (−1.7, 3.2) | +8.3 (1.7, 14.9) | +6.8 (2.1, 11.5) |
| Free T4h | |||||||||
| Low (vs. Medium) | −1.2 (−3.6, 1.3) | −0.7 (−2.8, 1.4) | −0.2 (−1.8, 1.5) | −0.6 (−1.9, 0.6) | +1.2 (−6.9, 9.3) | +0.2 (−5.0, 5.3) | −0.4 (−2.0, 1.2) | −1.0 (−5.4, 3.4) | −0.5 (−3.4, 2.4) |
| Medium | 8.3 (6.3, 10.3) | 4.9 (3.2, 6.7) | 9.8 (8.5, 11.2) | 8.5 (7.3, 9.7) | 35.8 (30.5, 41.2) | 30.1 (25.8, 34.5) | 9.4 (8.1, 10.7) | 28.6 (24.9, 32.2) | 19.6 (17.0, 22.3) |
| High (vs. Medium) | +0.6 (−1.1, 2.4) | +0.2 (−1.3, 1.7) | +0.1 (−1.1, 1.3) | +0.4 (−0.6, 1.3) | +1.4 (−4.0, 6.8) | −1.1 (−4.8, 2.6) | −0.3 (−1.4, 0.9) | −0.2 (−3.3, 3.0) | −0.1 (−2.3, 2.1) |
| Free T3i | |||||||||
| Low (vs.Medium) | −0.9 (−3.1, 1.2) | −0.7 (−2.7, 1.3) | −1.2 (−2.7, 0.3) | −1.4 (−2.7, −0.2) | −2.7 (−7.9, 2.4) | −3.1 (−7.9, 1.6) | −2.0 (−3.4, −0.6) | −5.4 (−9.3, −1.6) | −3.1 (−5.9, −0.3) |
| Medium | 8.7 (6.6, 10.8) | 5.1 (3.3, 7.0) | 10.3 (8.9, 11.7) | 8.8 (7.7, 10.0) | 37.2 (32.0, 42.5) | 29.0 (24.6, 33.4) | 9.4 (8.0, 10.7) | 28.5 (25.0, 32.1) | 19.4 (16.8, 22.0) |
| High (vs. Medium) | −0.3 (−2.7, 2.2) | −0.3 (−2.5, 1.8) | +0.3 (−1.4, 1.9) | +0.7 (−0.5, 2.0) | +2.6 (−3.3, 8.4) | +5.2 (0.0, 10.4) | +1.5 (−0.1, 3.1) | +5.2 (1.4, 8.9) | +3.3 (0.6, 6.0) |
Predicted mean hormone levels presented for medium level and β-coefficients presented for low and high levels representing mean estimated differences between low and medium levels and high and medium levels, respectively
All models control for age
Thyroid hormones modeled continuously and estimates output at the low (12.5th percentile), medium (50th percentile), and high (87.5th percentile) levels
TSH modeled as natural log-transformed
Low=0.80, Medium=1.4, High=3.0 μIU/ml
Low=7.5, Medium=8.9, High=10.5 μg/dl
Low=85, Medium=107, High=134 ng/dl
Low=0.65, Medium=0.77, High=0.86 ng/dl
Low=2.9, Medium=3.2, High=3.8 pg/ml