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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Pediatr Blood Cancer. 2018 Mar 7;65(7):e27035. doi: 10.1002/pbc.27035

TABLE 1.

Proposed dose escalation schema

Dosage Level Dasatinib (mg/m2 per dose) Crizotinib (mg/m2 per dose)
Twice-daily regimen 0 50 100
1 * 50 130
2 65 130
3a 65 165
3b 85 130
4 85 165
5 85 215
Once-daily regimen 0 50 130
1 * 50 165
2a 50 215
2b 65 165
3 65 215
4a 65 280
4b 85 280
*

Starting dosage level