Table 2.

Change of Descriptors in Relationship to cSLE Disease Course ^†

Flare Descriptors	Rule	Mean ± SE				Adjusted p-value
		(1) Improved/No change	(2) Minor Flare	(3) Moderate Flare	(4) Major Flare	(1) vs. (2)	(2) vs. (3)	(3) vs. (4)
ESR	Majority rule	−0.02 ± 1.30	8.81 ± 1.34	22.80 ± 1.38	28.99 ± 1.68	<0.0001	<0.0001	0.023
	67% rule	0.54 ± 1.58	7.28 ± 2.07	31.95 ± 2.39	35.34 ± 2.41	0.048	0.000	0.749
MD global of disease activity	Majority rule	0.66 ± 0.50	3.05 ± 0.52	5.92 ± 0.53	7.95 ± 0.65	0.005	0.001	0.075
	67% rule	0.76 ± 0.60	2.70 ± 0.79	7.74 ± 0.91	9.79 ± 0.92	0.210	<0.0001	0.392
Protein-creatinine ratio	Majority rule	0.02 ± 0.07	0.10 ± 0.07	0.66 ± 0.07	1.44 ± 0.08	0.843	<0.0001	<0.0001
	67% rule	0.03 ± 0.07	0.02 ± 0.09	0.64 ± 0.11	1.61 ± 0.11	1.000	<0.0001	<0.0001
SLEDAI	Majority rule	1.81 ± 0.26	4.58 ± 0.28	8.45 ± 0.29	16.00 ± 0.36	0.000	<0.0001	<0.0001
	67% rule	1.56 ± 0.35	4.63 ± 0.48	9.98 ± 0.56	19.88 ± 0.55	0.000	<0.0001	<0.0001
BILAG	Majority rule	3.12 ± 1.08	7.76 ± 0.93	15.19 ± 0.95	24.19 ± 1.15	0.007	<0.0001	<0.0001
	67% rule	1.79 ± 1.34	8.63 ± 1.50	15.64 ± 1.61	28.71 ± 1.75	0.005	0.010	<0.0001
SLEDAI-based Flare Algorithm	Majority rule	−0.23 ± 0.17	1.66 ± 0.18	4.79 ± 0.19	9.88 ± 0.23	<0.0001	<0.0001	<0.0001
	67% rule	−0.34 ± 0.21	1.67 ± 0.29	5.84 ± 0.34	12.34 ± 0.34	<0.0001	<0.0001	<0.0001
BILAG-based Flare Algorithm	Majority rule	0.40 ± 0.56	3.00 ± 0.48	7.10 ± 0.49	11.96 ± 0.60	0.003	<0.0001	<0.0001
	67% rule	−0.11 ± 0.66	3.49 ± 0.76	8.23 ± 0.79	15.05 ± 0.88	0.003	<0.0001	<0.0001

^†Values presented are changes in means (standard deviation) adjusted for multiple comparisons using the Tukey’s method.