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. Author manuscript; available in PMC: 2018 Nov 28.
Published in final edited form as: Nat Genet. 2018 May 28;50(6):834–848. doi: 10.1038/s41588-018-0127-7

Figure 2. Correlation of statistical significance and effect size of SNPs based on spherical equivalent (SphE) in diopters and age of diagnosis of myopia (AODM) in years.

Figure 2

(a) P comparison of all genetic variants with P < 1.0 × 10−3 (n=7249) between CREAM meta-analysis (Stage 1) and 23andMe (Stage 2) meta-analysis. Shown is the overlap (red) and the difference (green) in P signals per cohort for genetic variants. Green genetic variants are only genome wide significant in either CREAM or 23andMe. Blue: genetic variants with P between 5.0 × 10−8 and 1.0 × 10−3 in both CREAM and 23andMe. (b) Comparison of effects (SphE and logHR of AODM in years; P < 1.0 × 10−3; n=7249) between CREAM and 23andMe. Same color code was applied as in (a). The effects were concordant in their direction of effect on refractive error. We performed a simple linear regression between the effects of CREAM and 23andMe; the regression slope is -0.15 diopters per logHR of AODM in years.