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. Author manuscript; available in PMC: 2018 Nov 28.
Published in final edited form as: Nat Genet. 2018 May 28;50(6):834–848. doi: 10.1038/s41588-018-0127-7

Figure 4. Visualization of the DEPICT gene-set enrichment analysis based on loci associated with refractive error and the correlation between the (meta)gene sets.

Figure 4

(a) Shown are the 66 significantly enriched reconstituted gene sets clustered into thirteen meta gene sets based on the gene set enrichment analysis of DEPICT (pairwise Pearson correlations; P < 0.05). All genetic variants with a P < 1 × 10−5 in the GWAS meta-analysis of stage 3 (n=21,073) and an FDR < 0.05 were considered. (b) Visualization of the interconnectivity between gene sets (n=13; pairwise Pearson correlations; P < 0.05) of the meta gene set ‘Detection of Light Stimulus’ (GO:0009583). (c) Visualization of the interconnectivity between gene sets (n=27; pairwise Pearson correlations; P < 0.05) of the largest meta gene set ‘Thin Retinal Outer Nuclear Layer’ (MP:0008515). In all panels, (meta)gene sets are represented by nodes colored according to statistical significance, and similarities between them are indicated by edges scaled according to their correlation; Pearson’s r ≥ 0.2 are shown in panel (a) and Pearson’s r ≥ 0.4 are shown in panel (b,c).