Figure 6. Schematic representation of the human eye, retinal cell types, and functional sites of associated genes.

We assessed gene expression sites and/or functional target cells in the eye for all genes using our expression data and literature and data present in the public domain. The genes appear to be distributed across virtually all cell types in the neurosensory retina, in the RPE, vascular endothelium and extracellular matrix; i.e., the route of the myopic retina-to-sclera signalling cascade.