Table 3.

Change in oxygen uptake responses to walking after supplementation

	Placebo		L-citrulline		Placebo vs. Cit P value‡
	Change	P value†	Change	P value†
Young
Net VO2 (mL/kg/min)	−0.73 ± 0.39	NS	−0.73 ± 0.39	0.07	NS
MRT (s)	3.80 ± 1.83	0.05	−1.79 ± 1.83	NS	0.03
CI95 (s)	−0.46 ± 0.66	NS	0.54 ± 0.66	NS	NS
O2 deficit (L)	0.01 ± 0.04	NS	−0.10 ± 0.04	0.01	0.053
Older
Net VO2 (mL/kg/min)	−0.57 ± 0.45	NS	−0.01 ± 0.45	NS	NS
MRT (s)	2.59 ± 2.15	NS	−0.50 ± 2.15	NS	NS
CI95 (s)	−0.60 ± 0.78	NS	0.59 ± 0.78	NS	NS
O2 deficit (L)	−0.01 ± 0.05	NS	−0.05 ± 0.05	NS	NS
Women
Net VO2 (mL/kg/min)	−0.41 ± 0.38	NS	−0.16 ± 0.38	NS	NS
MRT (s)	2.93 ± 1.81	NS	2.26 ± 1.81	NS	NS
CI95 (s)	−0.74 ± 0.66	NS	0.76 ± 0.66	NS	NS
O2 deficit (L)	0.01 ± 0.04	NS	0.01 ± 0.04	NS	NS
Men
Net VO2 (mL/kg/min)	−0.89 ± 0.46	NS	−0.58 ± 0.46	NS	NS
MRT (s)	3.46 ± 2.17	NS	−4.54 ± 2.17	0.04	0.01
CI95 (s)	−0.32 ± 0.79	NS	0.38 ± 0.79	NS	NS
O2 deficit (L)	0.01 ± 0.05	NS	−0.15 ± 0.05	<0.01	0.02

Values are least square adjusted mean ± SE estimated from a single linear mixed model controlling for sequence and period effects of crossover design in addition to age and sex.

MRT, mean response time; CI₉₅, 95% confidence interval for rate constant; NS, non-significant (P > 0.05)

^†statistical significance of change scores before and after supplementation

^‡differences in change scores between placebo and L-citrulline conditions