SELECTION |
1. Selection of Sample |
Were the criteria for inclusion in the sample clearly defined? |
a) yes, low risk of bias (clear inclusion and exclusion criteria e.g., risk, stage of disease progression) |
b) yes, high risk of bias (e.g., not stated in part (a)) |
c) no description, unclear risk of bias |
EXPOSURE |
1. Ascertainment of exposure |
Was the exposure measured in a valid and reliable way? |
a) yes, low risk of bias (clearly describe the method of measurement of exposure, assessing validity requires a ’gold standard’, reliability refers to intra and inter-observed reliability) |
b) yes, high risk of bias (e.g., not stated in part (a)) |
c) no description of source, unclear risk of bias |
2. Ascertainment of outcome |
Were the outcome measured in the valid and reliable way? |
a) yes, low risk of bias (e.g., measurement tools used were validated instruments; e.g., histological proved) |
b) yes, high risk of bias (e.g., not stated in part (a)) |
c) no description of source, unclear risk of bias |
3. Confounding factors |
Were confounding factors indentified? |
a) yes, low risk of bias (strategies to deal with effects of confounding factors e.g., study design or in data analysis (multiple analysis), matching or stratifying sampling of participants |
b) yes, high risk of bias (e.g., not stated in part (a)) |
c) no description of source, unclear risk of bias |
4. Non-Response rate |
a) yes, low risk of bias (e.g., same rate for both groups) |
b) yes, high risk of bias (e.g., non-respondents described; rate different and no designation) |
c) no description of source, unclear risk of bias |