Table 7.
Genotype Frequency of the BRCA1 Gene rs8176318 Polymorphism in Different Populations (Yang et al.,2016)
| Populations | Sample | Genotype frequency, n (%) | Allele frequency, % | |||
|---|---|---|---|---|---|---|
| N | GG | GT | TT | G | T | |
| CEU | 226 | 100 (44.2) | 102 (45.1) | 24 (10.6) | 66.8 | 33.2 |
| CHB | 82 | 38 (46.3) | 32 (39.0) | 12 (14.6) | 65.9 | 34.1 |
| GIH | 176 | 52 (29.5) | 92 (52.3) | 32 (18.2) | 55.7 | 44.3 |
| CHD | 170 | 48 (28.2) | 96 (56.5) | 26 (15.3) | 56.5 | 43.5 |
| YRI | 226 | 180 (79.6) | 42 (18.6) | 4 (1.8) | 88.9 | 11.1 |
| LWK | 180 | 152 (84.4) | 26 (14.4) | 2 (1.1) | 91.7 | 8.3 |
| JPT | 172 | 88 (51.2) | 72 (41.9) | 12 (7.0) | 72.1 | 27.9 |
| MEX | 98 | 62 (63.3) | 28 (28.6) | 8 (8.2) | 77.6 | 22.4 |
| ASW | 98 | 56 (57.1) | 42 (42.9) | 0 (0) | 78.6 | 21.4 |
| MKK | 286 | 206 (72.0) | 72 (25.2) | 8 (2.8) | 84.6 | 15.4 |
| TSI | 176 | 68 (38.6) | 88 (50.0) | 20 (11.4) | 63.6 | 36.4 |
| Saudi Arabia | 100 | 45(45) | 50(50%) | 5(5%) | 70.5 | 30.3 |
CEU, Utah residents with Northern and Western European ancestry from the Center for the Study of Human Polymorphisms collection; JPT, Japanese individuals in Tokyo, Japan; YRI, members of the Yoruba tribe in Ibadan, Nigeria; CHB, Han Chinese individuals in Beijing, China; LWK, members of the Luhya tribe in Webuye, Kenya; MEX, individuals of Mexican ancestry in Los Angeles, California; GIH, Gujarati Indians in Houston, Texas; CHD, Chinese individuals in Metropolitan Denver, Colorado; ASW, individuals of African ancestry in Southwest, USA; MKK, members of the Maasai tribe in Kinyawa, Kenya; TSI, Tuscan individuals in Italy; HWP, Hardy-Weinburg probability; T, thymine; G, guanine.