Table 2.
Abnormal Karyotype and Corresponding FISH Results of the Study Group for All the Hematological Malignancies.
| SN | Karyotype | Fish Panel | ||||
|---|---|---|---|---|---|---|
| Multiple Myeloma | 1p32 (CDKN2C) | 1q21 (CKS1B) | 14q32 (IGH) | 13q14 (D13S319/ LAMP1) | 17p13 (p53) | |
| 1 | 43,-X,-Y,+1,t(1;8)(p14;q24),-2,-4,add(7)(p21), t(13;14)(q10;q10), del(13)(q14;q32), add(16)(p13),+22 [12]/46,XY[8] | 3G | 3-5R | 1Y | 1G1R | 2G2R |
| 2 | 46-48,X,-X,+del(1)(q32),-3,add(4)(q33),-5, del(6) (q15), 10,+add(11)(q23), add(12)(p13)x2, ?del(13) (q32),-15, -17,+18, -20, +4 mar [12]/46,XX[2] | 2G | 3R | 1Y | 1R1G | 1G1R |
| 3 | 54,XY,del(1)(p13p32),del(1)(p13),+1,+3,+5,+7,+8,+9, +10,-13,+21, +21 [16]/46,XY[4] | 2G | 3R | 1Y1G1R | 1R1G | 2G2R |
| 4 | 57,X,-Y,+2,+3,+4,+5,+6,-8, +9,+11, +13,+14, +15, +17,+19,20,+21,+22[5] /46,XY[15] | 2G | 3R | 2Y | 2G2R | 3G3R |
| Chronic Lymphocytic Leukemia | 6q23 (MYB/SEC63) | CEP 12 | 13q14 (D13S319) | 11q22 (ATM) | 17p13 (p53) | |
| 5 | 47,XX,+12[5]/46,XX[25] | 2R2G | 3G | 2R2B | 2R | 2G |
| Acute Lymphocytic Leukemia | t(9;22)(q34;q11) (BCR/ABL1) | t(12;21)(p13;q22) (ETV6/RUNX1) | 11q23 (MLL) | |||
| 6 | 46,XX, t(9;22))(q34;q11) [10]/46,XX[5] | 1G1R2Y | 2G2R | 1Y | ||
| 7 | 46,XY,t(3;12;21)(p13;p13;q22),del(6)(q21),add(12)(p13),del(17)(q22) [12] /46,XY[8] | 2G2R | 2G2R1Y | 1Y | ||
| 8 | 46,XY,t(9;22)(q34;q11)[7]/46,XY,t(2;3)(q31;q27),t(9;22)(q34;q11)[3] | 1G1R2Y | 2G2R | 2Y | ||
| 9 | 46,XX[13]/58,XX,+4,+5,+6,+8,+9,+10, +11,+12,+14, +15,+21,+21[2] | 2G2R | 2R4G | 2Y | ||
| 10 | 46,XY ,?add(9)(p), t(9;22)(q34;q11)[15] | 1G1R2Y | 2G2R | 2Y | ||
| 11 | 52,XY,+X,+6,+14,+17,+21,+21[20] | 1G1R2Y | 2R3G/2R4G | 2Y | ||
| 12 | 46,XX,del(2)(q11),t(10;11)(p13;q23),der(14)t(1;14)(q21;p11)[16]/ 46,XX[4] | 1G1R2Y | 1G1R2Y | 1Y1G1R | ||
| 13 | 47,XX,add(7)(p11),-11,der(12)t(12;?)(p11;?), -20,+21, -22,+3-4 mar [9]/ 46,XX[16] | 1G1R2Y | 1R3G | 2Y | ||
| 14 | 60,XY,+X,dirdup(1)(q21-qter) ,+4,+6, +7, +9, +14, +15,+17, +20, +21, +3 mar[15] | 2G2R | 2R4G | 2Y | ||
| 15 | 45,XY,t(9;22)(q34;q11),-18, der(20)t(18;20) (q11;q13) [20] | 2G1R1F | 2G2R | 2Y | ||
| 16 | 51-60,XX,-Y,add(2 p21),+add(3p21)x2,+del (4q24), +8,+21,+21[15] | 2G2R | 2R3G/2R4G | 2Y | ||
| 17 | 54,XY,+X,+4,+5,+i(7)(q10),+8,+10,+14, +21[18] | 2G2R | 2R3G | 2Y | ||
| 18 | 46,del(1q31),?dup(2q21q31),del(9p13),del(14q) [19]/46,XY[1] | 2G2R | 2G2R | 2Y | ||
| 19 | 44-46,X,-Y,-5,add(7)(p12),add(12),(p11),+1,-2 mar[13] /46,XY[7] | 2G2R | 2G1R | 2Y | ||
| 20 | 46-48,XY,+1,-2mar[12] | 2G2R | 2R1Y | 2Y | ||
| 21 | 46,XY,t(2;5)(q21;p15)[20] | 2G2R | 2G2R | 2Y | ||
| 22 | 46,XY,t(9;15)(q34;q11),?del(13)(q14)[12]/46,XY[8] | 2G2R | 2G2R | 2Y | ||
| 23 | 46, XY t(2;7)(p14;p22) [15] / 46,XY[5] | 2G2R | 2G2R | 2Y | ||
| 24 | 46,XY,i(7)(q10), del(9)(p13)[7]/46,XY[1] | 2G2R | 2G2R | 2Y | ||
| 25 | 46,i(X)(q10),Y[20] | 2G2R | 2G2R | 2Y | ||
| Myelodysplastic Syndrome | -5q31/-5q32-33 (EGR1/RPS14) | -7q22/-7q31 (MLL5/MET) | CEP 8 | -20q12/-20q13 (PTPRT/ MYBL2 | ||
| 26 | 45,XX,-7[1] | 2G2R | 1R1G | 2B | 2G2R | |
| 27 | 45,XX,-7[30] | 2G2R | 1G1R | 2B | 2G2R | |
| 28 | 45,XX,-7,del(20)(q12)[15] | 2G2R | 1G1R | 2B | 1G1R | |
| 29 | 46,XX,del(5)(q21)[10] | 1G2R | 2G2R | 2B | 2G2R | |
| 30 | 60,XY,+X,add(1)(p35),+5,+5,+5,+del(6)(q23),+7,+10, +12,+14,+15,+17,+18,+21,+22/46,XY,del(6)(q23) [3]/46,XY[20] | 3G3R | 3G3R | 2B | 2G2R | |
| 31 | 47,XX,+8[1] | 2G1R | 2G2R | 3B | 2G2R | |
| 32 | 45,XY,t(3;11)(p?;q32),-5[8] | 1G1R | 2G2R | 2B | 2G2R | |
| 33 | 47,XX,dup(5)(q13;q31),+8,del(14)(q23;q32)[10] | 2G1R | 2R2G | 3B | 2G2R | |
| 34 | 47,XY,del(3)(q22),-5,?del (7)(q32q33),+8,+15, ?del(20)(q13)[6] | 2G1R | 1R1G | 3B | 1R1G | |
| 35 | 46,XY,trp(1)(q21;q32),add(3)(q26),add(19)(p13)[15] | 2G2R | 2G2R | 2B | 2G2R | |
| 36 | 46,XY,t(6;9)(p22;q34)[20] | 2G2R | 2G2R | 2B | 2G2R | |