Table 3.
Genotype and Allele Frequencies of CYP2D6*4, CYP2D6*10, CYP3A5*3 & CYP2C19*2 Gene Polymorphism in the South Indian Women with Breast Cancer
| CYP2D6*4 | Cases (110) | Controls (100) | Odds Ratio | 95% CI | P- Value |
|---|---|---|---|---|---|
| GG | 87 (79%) | 96 (96%) | 0.156 | 0.0524 to 0.4738 | P = 0.0010 |
| GA | 17 (15%) | 4 (4%) | 4.3871 | 1.4230 to 13.5257 | 0.0101 |
| AA | 6 (6%) | 0 (00%) | 12.5 | 0.6952 to 224.8466 | 0.0866 |
| G Allele | 191 (86.8%) | 196 (89.0) | 0.1344 | 0.0464 to 0.3896 | 0.0002 |
| A Allele | 29 (13.18) | 4 (2%) | |||
| CYP2D6*10 | Cases (110) | Controls | Odds Ratio | 95% CI | P- Value |
| CC | 83 (75%) | 92 (92%) | 0.2673 | 0.1151 to 0.6210 | 0.0022 |
| CT | 24 (23%) | 7 (7%) | 3.7076 | 1.5202 to 9.0425 | 0.004 |
| TT | 3 (2%) | 1 (1%) | 2.6075 | 0.2666 to 25.4977 | 0.4101 |
| C Allele | 190 (86.3%) | 192 (96%) | 0.2969 | 0.1373 to 0.6421 | 0.002 |
| T Allele | 30 (13.6) | 9 (4.5%) | |||
| CYP3A5*3 | Cases (110) | Controls | Odds Ratio | 95% CI | P- Value |
| AA | 97 (88%) | 95 (95%) | 0.3927 | 0.1348 to 1.1444 | 0.0867 |
| AG | 11 (10%) | 5 (5%) | 2.1111 | 0.7070 to 6.3041 | 0.1807 |
| GG | 2 (2%) | 0 (00%) | 4.6313 | 0.2197 to 97.6476 | 0.3244 |
| A Allele | 205 (93.1%) | 195 (97.5%) | 0.3504 | 0.1250 to 0.9825 | 0.0462 |
| G Allele | 15 (6.8) | 5 (2.5%) | |||
| CYP2C19*2 | Cases (110) | Controls | Odds Ratio | 95% CI | P- Value |
| GG | 93 (85%) | 97 (97%) | 0.1692 | 0.0480 to 0.5964 | 0.0057 |
| GA | 13 (12%) | 3 (3%) | 4.3333 | 1.1969 to 15.6881 | 0.0255 |
| AA | 4 (3%) | 0 | 8.493 | 0.4515 to 159.7675 | 0.1531 |
| G Allele | 199 (90.4%) | 197 (98.5%) | 0.1443 | 0.0424 to 0.4916 | 0.002 |
| A Allele | 21 (9.5%) | 3 (1.5%) | |||