Table 4.
Correlation of Breast Cancer Patients Demographic Factors and CYP2D6*4 Genotype Frequencies
| Characteristics | Cases (n=110) | EM (n=87) | IM (n=17) | PM (n=6) | P- Value |
|---|---|---|---|---|---|
| Age of Diagnosis | |||||
| 21-30 | 10 (9%) | 9 (90%) | 1 (10%) | 0 (0%) | |
| 31-40 | 26 (24%) | 23 (89 %) | 2 (8 %) | 1 (3%) | |
| 41-50 | 44 (40%) | 36 (82%) | 6 (13%) | 2 (5%) | |
| 51-60 | 22 (20%) | 11 (50%) | 8 (36%) | 3 (14%) | 0.001 |
| 61-70 | 8 (7%) | 8 (100%) | 0 (00%) | 0 (00%) | |
| Menopausal Status | |||||
| Post Menopausal | 65 (60%) | 50 (77%) | 12 (19%) | 3 (4%) | 0.31 |
| Premenopausal | 45 (40%) | 37 (83%) | 5 (11%) | 3 (6%) | |
| Hormone Receptor status | |||||
| ER /PR Positive | 56 (66%) | 43 (76%) | 11 (20%) | 2 (4%) | 0.57 |
| ER/PR Negative | 42 (25%) | 32 (76%) | 6 (14%) | 4 (10%) | |
| HER2 neu Positive | 79 (25%) | 64 (82%) | 10 (12%) | 5 (6%) | 0.22 |
| HER2 neu Negative | 31 (25%) | 23 (74%) | 7 (22%) | 1 (3%) | |
| Triple Negative | 29 (26%) | 16 (55%) | 9 (31%) | 4 (14%) | |
| Histological Grade | |||||
| Grade I | 23 (41%) | 21 (92%) | 2 (8%) | 0 (0%) | 0.27 |
| Grade II | 53 (41%) | 40 (68%) | 10 (30%) | 3 (2%) | |
| Grade III | 34 (18%) | 26 (65%) | 5 (22%) | 3 (13%) | |
| Therapy | |||||
| FAC/Tamoxifen | 63 (57%) | 47 (75%) | 11 (17%) | 5 (8%) | 0.04 |
| FAC | 36 (31%) | 30 (80%) | 5 (14%) | 1 (6%) | |
| Unknown | 11 (12%) | 10 (91%) | 1 (9%) | 0 (0%) |