Table 5.
Correlation of Breast Cancer Patients Demographic Factors and CYP2D6*10 Genotype Frequencies
| Characteristics | Cases (n=110) | EM (n=83) | IM (n=24) | PM (n=3) | P- Value |
|---|---|---|---|---|---|
| Age of Diagnosis | |||||
| 21-30 | 10 (9%) | 10 (100%) | 0 (00%) | 0 (00%) | |
| 31-40 | 26 (24%) | 23 (89 %) | 3 (8 %) | 0 (0%) | 0.02 |
| 41-50 | 44 (40%) | 27 (82%) | 14 (13%) | 3 (5%) | |
| 51-60 | 22 (20%) | 15 (50%) | 7 (36%) | 0 (00%) | |
| 61-70 | 8 (7%) | 8 (100%) | 0 (00%) | 0 (00%) | |
| Menopausal Status | |||||
| Post Menopausal | 65 (60%) | 47 (77%) | 15 (19%) | 3 (4%) | 0.6 |
| Premenopausal | 45 (40%) | 36 (83%) | 9 (11%) | 0 (0%) | |
| Hormone Receptor status | |||||
| ER /PR Positive | 56 (66%) | 41 (76%) | 14 (20%) | 1 (4%) | 0.98 |
| ER/PR Negative | 42 (25%) | 29 (76%) | 10 (14%) | 3 (10%) | |
| HER2 neu Positive | 79 (25%) | 59 (75%) | 17 (21%) | 3 (4%) | 0.98 |
| HER2 neu Negative | 31 (25%) | 24 (77%) | 7 (22%) | 0 (00%) | |
| Triple Negative | 29 (26%) | 16 (55%) | 12 (41%) | 1 (3%) | |
| Histological Grade | |||||
| Grade I | 23 (41%) | 23 (100%) | 0 (00%) | 0 (00%) | |
| Grade II | 53 (41%) | 36 (68%) | 16 (30%) | 1 (2%) | 0.04 |
| Grade III | 34 (18%) | 24 (70%) | 8 (24%) | 2 (6%) | |
| Therapy | |||||
| FAC/Tamoxifen | 63 (57%) | 40 (63%) | 14 (22%) | 3 (5%) | 0.002 |
| FAC | 36 (31%) | 28 (77%) | 8 (23%) | 0 (0%) | |
| Unknown | 11 (12%) | 9 (82%) | 2 (18%) | 0 (0%) |