Table 6.
Correlation of Breast Cancer Patients Demographic Factors and CYP3A5*3 Genotype Frequencies
| Characteristics | Cases (n=110) | EM (n=97) | IM (n=11) | PM (n=2) | P-Value |
|---|---|---|---|---|---|
| Age of Diagnosis | |||||
| 21-30 | 10 (9%) | 10 (100%) | 0 (00%) | 0 (00%) | |
| 31-40 | 26 (24%) | 26 (100 %) | 0 (00 %) | 0 (3%) | |
| 41-50 | 44 (40%) | 34 (77%) | 8 (19%) | 2 (4%) | |
| 51-60 | 22 (20%) | 19 (87%) | 3 (13%) | 0 (00%) | |
| 61-70 | 8 (7%) | 8 (100%) | 0 (00%) | 0 (00%) | 0.02 |
| Menopausal Status | |||||
| Post Menopausal | 65 (60%) | 56 (77%) | 7 (19%) | 2 (4%) | 0.7 |
| Premenopausal | 45 (40%) | 41 (83%) | 4 (11%) | 0 (0%) | |
| Hormone Receptor status | |||||
| ER /PR Positive | 56 (66%) | 41 (76%) | 5 (20%) | 0 (4%) | 0.56 |
| ER/PR Negative | 42 (25%) | 34 (76%) | 6 (14%) | 2 (10%) | |
| HER2 neu Positive | 79 (25%) | 59 (75%) | 8 (21%) | 3 (4%) | 0.98 |
| HER2 neu Negative | 31 (25%) | 24 (77%) | 3 (23%) | 0 (00%) | |
| Triple Negative | 29 (26%) | 20 (68%) | 8 (28%) | 1 (4%) | |
| Histological Grade | |||||
| Grade I | 23 (41%) | 23 (100%) | 0 (00%) | 0 (00%) | |
| Grade II | 53 (41%) | 45 (85%) | 8 (15%) | 0 (00%) | 0.11 |
| Grade III | 34 (18%) | 29 (85%) | 3 (91%) | 2 (6%) | |
| Therapy | |||||
| FAC/Tamoxifen | 63 (57%) | 52 (83%) | 9 (14%) | 2 (3%) | 0.09 |
| FAC | 36 (31%) | 34 (95%) | 2 (5%) | 0 (0%) | |
| Unknown | 11 (12%) | 11 (100%) | 0 (00%) | 0 (0%) |