Table 7.
Correlation of Breast Cancer Patients Demographic Factors and CYP2C19*2 Genotype Frequencies
| Characteristics | Cases (n=110) | EM (n=93) | IM (n=13) | PM (n=4) | P- Value |
|---|---|---|---|---|---|
| Age of Diagnosis | |||||
| 21-30 | 10 (9%) | 10 (100%) | 0 (00%) | 0 (00%) | |
| 31-40 | 26 (24%) | 24 (100 %) | 2 (00 %) | 0 (3%) | |
| 41-50 | 44 (40%) | 22 (77%) | 8 (19%) | 4 (4%) | 0.008 |
| 51-60 | 22 (20%) | 19 (87%) | 3 (13%) | 0 (00%) | |
| 61-70 | 8 (7%) | 8 (100%) | 0 (00%) | 0 (00%) | |
| Menopausal Status | 0.36 | ||||
| Post Menopausal | 65 (60%) | 52 (77%) | 9 (19%) | 4 (4%) | |
| Premenopausal | 45 (40%) | 41 (83%) | 4 (11%) | 0 (0%) | |
| Hormone Receptor status | |||||
| ER /PR Positive | 56 (66%) | 48 (76%) | 6 (20%) | 2 (4%) | 0.37 |
| ER/PR Negative | 42 (25%) | 33 (76%) | 7 (14%) | 2 (10%) | |
| HER2 neu Positive | 79 (25%) | 65 (75%) | 10 (21%) | 4 (4%) | 0.6 |
| HER2 neu Negative | 31 (25%) | 28 (77%) | 3 (23%) | 0 (00%) | |
| Triple Negative | 29 (26%) | 20 (68%) | 8 (28%) | 1 (4%) | |
| Histological Grade | |||||
| Grade-I | 23 (41%) | 23 (100%) | 0 (00%) | 0 (00%) | 0.14 |
| Grade II | 53 (41%) | 45 (85%) | 8 (15%) | 3 (00%) | |
| Grade III | 34 (18%) | 29 (85%) | 5 (91%) | 1 (6%) | |
| Therapy | |||||
| FAC/Tamoxifen | 63 (57%) | 48 (83%) | 11 (14%) | 4 (3%) | 0.03 |
| FAC | 36 (31%) | 34 (95%) | 2 (5%) | 0 (0%) | |
| Unknown | 11 (12%) | 11 (100%) | 0 (00%) | 0 (0%) |