Table 3.
The Relation between the Percentages of the Positive Samples for AKAP4 Gene Expression and Clinicopathological Data at Diagnosis
| AKAP4 Expression percentage | ||||
|---|---|---|---|---|
| Clinical Factor | Number of cases | - | + | P-value |
| Gender | Male (n=27) | 33 | 67 | |
| Female (n=34) | 50 | 50 | 0.207 | |
| Age (years) | >50 (n=39) | 62 | 38 | |
| ≤50 (n=21) | 48 | 52 | 0.414 | |
| T category | Tx (n=2) | 50 | 50 | |
| T1 (n=5) | 60 | 40 | ||
| T2 (n=14) | 79 | 21 | 0.301 | |
| T3 (n=30) | 43 | 57 | ||
| T4 (n=9) | 56 | 44 | ||
| T category (B) | TX & T1 & T2 (n= 21) | 73 | 27 | |
| T3 & T4 (n=39) | 45 | 55 | 0.059 | |
| M category | M0 (n=51) | 63 | 37 | |
| M1 (n=11) | 27 | 73 | 0.045* | |
| N category (A) | N0 (n=31) | 61 | 39 | |
| N1 (n=22) | 50 | 50 | 0.715 | |
| N2 (n=9) | 56 | 44 | ||
| N category (B) | N0 (30) | 63 | 37 | |
| N1 & N2 (31) | 52 | 48 | 0.44 | |
| Tumor Size(A) (centimeters) | 1.5-3 (n=22) | 55 | 45 | |
| 3.1-5.5 (n=19) | 53 | 47 | 0.889 | |
| 5.6-12 (n=20) | 60 | 40 | ||
| Relapse | - (n=43) | 61 | 39 | |
| +(n=13) | 38 | 62 | 0.21 | |
| Stage | Stage 0 (n=6) | 50 | 50 | |
| Stage 1 (n=14) | 79 | 21 | ||
| Stage 2 (n=19) | 37 | 63 | 0.192 | |
| Stage 3 (n=16) | 62 | 38 | ||
| Stage 4 (n=7) | 57 | 43 | ||
*
p < 0.05 significance association between gene expression and clinical risk factors; T category, The rate of growth and progression of tumors in the intestinal wall layers based on the pathological division. M, Metastasis to other organs (M0, non metastati; M, metastatic). N, Lymph node involvement (N0, no involvement); Tumor Size, The length of tumors in centimeters; Relapse, Tumor Recurrence (+: Recurrence, -: no Recurrence); Stage, Stage of cancer according to TNM classification System and pathological data.