Table 7.
Pharmacokinetic parameters of TSG, emodin and EDG in rats.
| Parameters | Unit | TSG |
Emodin |
EDG |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| TE group | HDP group | CAP group | TE group | HDP group | CAP group | FAP group | TE group | HDP group | CAP group | ||
| Tmax | h | 0.25 ± 0.14 | 0.3 ± 0.07 | 0.28 ± 0.14 | 1.61 ± 3.13 | 4.81 ± 3.74 | 0.22 ± 0.08 | 1.11 ± 1.59 | 0.28 ± 0.13 | 0.25 ± 0.09 | 0.2 ± 0.07 |
| Cmax | ng/mL | 69.62 ± 51.79 | 211.39 ± 100.81∗ | 7.83 ± 8.04 | 86.66 ± 19.74 | 8.6 ± 2.2 | 165.06 ± 0.14# | 30.96 ± 4.03# | 21.52 ± 25.64 | 10.82 ± 7.73 | 17.91 ± 15.35 |
| AUC0-24 | ng h/mL | 80.39 ± 34.36 | 134.08 ± 94.04 | 1.2 ± 0.92 | 480.03 ± 66.78 | 50.69 ± 9.5∗ | 314.48 ± 56.72# | 121.43 ± 43.50# | 9.22 ± 13.58 | 1.51 ± 1.07 | 7.44 ± 10.29 |
| AUC0-∞ | ng h/mL | 90.24 ± 35.81 | 137.77 ± 93.26 | 1.14 ± 1.05 | 506.31 ± 61.62 | 64.25 ± 20.15∗ | 376.12 ± 50.03# | 138.89 ± 45.86# | 14.35 ± 15.92 | 3.32 | 10.39 ± 13.73 |
| thalf | h | 2.21 ± 1.6 | 0.9 ± 0.68∗ | 0.12 ± 0.05 | 5.01 ± 1.68 | 4.39 ± 0.52 | 4.44 ± 0.73 | 4.43 ± 0.89 | 0.18 ± 0.13 | 0.21 | 0.36 ± 0.11 |
| MRT | h | 3.92 ± 3.48 | 1.03 ± 0.41∗ | 0.29 ± 0.05 | 9.22 ± 0.97 | 9.18 ± 0.53 | 7.37 ± 0.61# | 6.54 ± 1.39# | 0.44 ± 0.21 | 0.47 | 0.66 ± 0.2 |
The data are represented as the mean ± SD, n = 6. ∗P < 0.05, comparison between the TE group and HDP group. #P < 0.05, CAP group and FAP group compared with TE group.