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. 2018 May 19;7(5):45. doi: 10.3390/cells7050045

Figure 4.

Figure 4

Immune memory response categories defined with representative donors shown. Response Category A consists of donors who showed a clearly positive (as defined in Materials and Methods) anti-I-HCMV and anti-HCMVpp65 T-cell response while also displaying memory B cells specific for I-HCMV. Representative wells are shown for Donor 2, who falls into this category. Response Category B consisted of donors who displayed I-HCMV- and HCMVpp65-reactive T cells (thus CD4+ and CD8+ memory cells) in elevated frequencies, but who had no detectable HCMV-specific memory B cells. Representative wells are shown for Donor 34, who falls into this category. Donors in Response Category C displayed T cells responding to I-HCMV (i.e., CD4+ cells, see Figure 2A) but in the absence of HCMVpp65-reactive T cells and B cells. Representative wells are shown for Donor 59, who falls into this category. Finally, donors of Response Category D did not show detectable frequencies of either memory cell type and therefore appeared to be immunologically naïve to HCMV. Representative wells are shown for Donor 75, who falls into this category.