Table 2.
Mortality risk by Body Mass Index (BMI) category at the time of diabetes diagnosis stratified by weight trajectory patterns before diagnosis
| BMI category | |||||
|---|---|---|---|---|---|
| Normal weight (N = 10,534) | Overweight (N = 38,848) | Grade 1 Obese (N = 55,559) | Grade 2 Obese (N = 23,844) | Grade 3 Obese (N = 16,013) | |
| Lost body weight (LBW, n = 27,589) | |||||
| Patientsa | 2983 (28) | 8266 (21) | 9721 (17) | 3977 (17) | 2544 (16) |
| Deathsa | 205 (2) | 543 (1) | 520 (1) | 171 (1) | 120 (1) |
| Person-time in yearsb | 1093 | 2957 | 2327 | 1008 | 667 |
| Rate per 1000 person-years | 11.0 (9.6,12.7) | 11.1 (10.2,12.1) | 10.6 (9.7,11.6) | 8.6 (7.42, 10.1) | 9.8 (8.2,11.9) |
| HR (95% CI)c | 0.89 (0.65,1.22) | 0.93 (0.77,1.12) | 1.00 (reference) | 1.01 (0.81,1.27) | 1.30 (0.86,1.95) |
| No weight loss (NWL, n = 117,469) | |||||
| Patientsa | 7551 (72) | 30,582 (79) | 45,838 (83) | 19,867 (83) | 13,469 (84) |
| Deathsa | 559 (5) | 1901 (5) | 2639 (5) | 883 (4) | 633 (4) |
| Person-time in yearsb | 3069 | 10,981 | 14,443 | 5411 | 3826 |
| Rate per 1000 person-years | 12.4 (11.4, 13.5) | 10.0 (9.5,10.4) | 9.7 (9.3,10.1) | 8.1 (7.6,8.7) | 8.9 (8.2,9.7) |
| HR (95% CI)c | 1.35 (1.17,1.55) | 0.99 (0.91,1.07) | 1.00 (reference) | 0.95 (0.86,1.04) | 1.06 (0.89,1.25) |
aNumber (proportion)
bPerson-time (years) contributed by patients who died during follow-up. Follow-up period from 2000 to 2014
cEstimates of hazards ratios (HR) were adjusted for sex, smoking status, deprivation score, insulin, oral antidiabetic drugs, cardio-protective medicine and time varying incidence of cancer, chronic kidney disease and incidence of any cardiovascular disease using age group at baseline as stratification factor