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. 2018 May 25;9:1105. doi: 10.3389/fmicb.2018.01105

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Copyright © 2018 Song, Zhang, Cai, Lv, Zhao, Wei and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deletion of htsA reduced GAS systemic dissemination in mice. Groups of mice (n = 7) were infected with ∼2 × 10⁸ CFU of GAS strains, and then the GAS load in heparinized blood and tissue homogenates from spleen, liver, kidneys, and lungs was determined at 24 h postinoculation. The GAS load in samples was expressed as log₁₀ CFU. GAS log₁₀ CFU values in the spleen, liver, and kidneys of mice infected with ΔhtsA were significantly lower than those observed in mice infected with wild type, and ΔhtsA-htsA could restore the virulence of GAS. ^∗P < 0.05, ^∗∗P < 0.01.