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. 2018 May 31;8:8449. doi: 10.1038/s41598-018-26800-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differences observed in the DENV4 (Philippines vs. New Caledonia) serotype that influence binding of the neutralizing antibody. (A) Amino-acid sequence alignment between DENV4 serotypes Philippines and New Caledonia, with the three mutated residues shown in red boxes. (B) Variant residues between the two DENV4 strains are shown as ball and sticks on the DIII structure. (C) Evolution of secondary structure for residues 363–365 in the respective DENV4 strains during MD simulations plotted using VMD. Residue 364 in New Caledonia adopts a disordered conformation.