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. 2018 May 31;8:8475. doi: 10.1038/s41598-018-26820-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Micro-CT-derived bone morphometry results revealed an increase in bone volume and bone mineral density in Prx1-CreERT; Bmpr1a^f/f mice. (a,b) Body weight and femur lengths of mutant and control littermates showed no significant difference. Data are expressed as mean ± SEM from 8 mice per group. (c) Representative micro-CT images of 2D whole femur segital section from adult Prx1-CreERT; Bmpr1a^f/f and their respective control mice. (d) 3D distal femoral metaphyseal cancellous bone (upper panel) and mid-diaphyseal cortical bone (lower panel). N = 8 mice per group. (e–j) Micro-CT quantification of bone histomorphometry indices revealed high trabecular bone mass in mutant mice. Tb. BMD, trabecular bone mineral density (g/cm³) (e); BS/TV, bone surface/tissue volume (mm²/mm³) (f); BV/TV, bone volume/tissue volume (%) (g); Tb.Th, trabecular thickness (mcm) (h); Tb.Sp, trabecular spacing (mm) (i); and Tb.N, trabecular number (No./mm) (j). (k–n) Micro-CT quantification revealed high cortical bone phenotypes in mutant mice. Ct. BMD, Cortical bone mineral density (g/cm³) (k); Ct, BV/TV, cortical bone mass (%) (l); Ct. BV, cortical bone volume (mm³) (m); and Ct.Th, cortical thickness (mm) (n). N = 8 mice per genotype; ^*P < 0.05.