Table 1.
ERα interacting proteins
| S. No. | Name of the protein | Tissue specificity | Disease correlation |
|---|---|---|---|
| 1 | SRC-1 | Brain (hypothalamus, hippocampus, cerebellum, PVN) | Breast cancer, endometrial cancer |
| 2 | TIF2 | Pancreas, skeletal muscle, liver, lung, placenta, brain, heart | Colorectal cancer, acute mylemonocytic leukemia |
| 3 | GRIP1 | Muscle, neural tissue, mammary gland | Breast cancer |
| 4 | AIB1 | Heart, skeletal muscle, pancreas and placenta | Polycystic ovarian syndrome, ovarian cancer, breast cancer |
| 5 | ARA70 | Adipose tissue, testis | Polycystic ovarian syndrome, prostate cancer |
| 6 | NCoA3 | Heart, skeletal muscle, pancreas, and placenta | Breast cancer |
| 7 | CBP | Brain, skeletal muscles | Rubinstein-Taybi syndrome, Huntington's disease |
| 8 | pCAF | Intestines | Colorectal cancer |
| 9 | TRAP220 (MED1) | Ubiquitously present | Lung adenocarcinoma, crohn's disease |
| 10 | SRA | Mammary gland, ovaries, placenta, adipose tissue | Breast cancer, prostate cancer, ovarian cancer |
| 11 | p68 | Mammary gland, adipose tissue | Breast cancer |
| 12 | ASC-2 | Mammary gland, spleen, liver | Breast cancer |
| 13 | PNRC | Liver, lung, adipose tissue, NK/T cells | Hepatitis B, breast Cancer |
| 14 | SPBP (TCF20) | Brain, heart, testis, kidney, liver, lungs | Arrhythmia, cardiac problems |
| 15 | DHX9 | Neuronal cells, pituitary, ovary | Werner syndrome |
| 16 | STAU1 | Brain, pancreas, heart, skeletal muscles, liver, lung, kidney | Cardiac diseases, lung carcinomas |
| 17 | EIF4G | Heart, skeletal muscles | Encephalomyocarditis virus infection |
| 18 | PELP1 | Breast cancer cells | Endometrial cancer, breast cancer |
| 19 | PGC1 | Heart, brain, skeletal muscles | Obesity, type II diabetes |
| 20 | NRIP1 | Placenta, ovary, brain, lung, stomach, kidney | Post-menopausal osteoporosis, infertility |
| 21 | N-COR | Lung, spleen, brain, mammary gland | Breast cancer, myeloid leukemia |
| 22 | SMRT (NCOR2) | Ubiquitous, high levels in embryo | B-cell lymphoma, myeloid leukemia |
| 23 | RIP140 | Placenta, ovary, liver | Post-menopausal osteoporosis, infertility |
| 24 | CARM1 | High expression in prostate, epithelial cells | Prostate cancer, vascular diseases |
| 25 | SHP | Liver, heart, pancreas, placenta | Obesity, endometrial cancer, insulin resistance. |
| 26 | DAX | Adrenal gland, pituitary | Hypogonadism, congenital adrenal hyperplasia |
| 27 | HET-SAFB | Mammary gland, stomach, liver | Breast cancer, duodenal ulcer |