Table 2.
Changes in HRQoL scores from baseline (TO) to directly after 1-year treatment (T1) and at follow-up 1 year after treatment (T2)*
| % of total1 | HRQoL score |
Effects |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T0 mean (SE) | T1 mean (SE) | T2 mean (SE) | T1 vs. T0 adjusted 2 beta (95% CI) |
T2 vs. T1 adjusted 2 beta (95% CI) |
T2 months vs. T0 adjusted 2 beta (95% CI) |
||||||||||
| Genetic HRQoL | |||||||||||||||
| KIDSCREEN-10 | 69.7 | 48.4 (1.0) | 47.8 (1.0) | 49.8 (1.3) | −0.60 (−2.56; 1.36) | 2.05 (−0.10; 4.19) | 1.45 (−0.75; 3.64) | ||||||||
| KIDSCREEN-52 | |||||||||||||||
| Physical wellbeing | 72.5 | 41.1 (0.8) | 44.3 (0.8) | 45.3 (1.2) | 3.23 (1.46; 5.00) | 0.93 (−1.06; 2.92) | 4.16 (1.92; 6.39) | ||||||||
| Psychological wellbeing | 72.2 | 48.0 (1.0) | 49.3 (1.2) | 50.3 (1.4) | 1.29 (−0.90; 3.48) | 0.98 (−1.50; 3.45) | 2.27 (−0.22; 4.77) | ||||||||
| Moods and emotions | 72.5 | 44.6 (1.2) | 45.8 (1.3) | 47.1 (1.5) | 1.27 (−1.14; 3.68) | 1.26 (−1.22; 3.74) | 2.53 (0.09; 4.97) | ||||||||
| Self-perception | 72.5 | 40.0 (0.9) | 43.2 (0.8) | 42.5 (1.2) | 3.26 (1.69; 4.83) | −0.76 (−2.57; 1.05) | 2.50 (0.70; 4.31) | ||||||||
| Autonomy | 72.5 | 51.4 (0.9) | 49.5 (1.1) | 51.4 (1.2) | −1.93 (−4.06; 0.20) | 1.97 (−0.14; 4.07) | 0.04 (−2.23; 2.31) | ||||||||
| Parent relation and home life | 72.2 | 51.1 (1.3) | 48.8 (1.4) | 50.0 (1.5) | −2.30 (−4.57; −0.03) | 1.16 (−1.29; 3.61) | −1.14 (−3.54; 1.27) | ||||||||
| Financial resources | 71.4 | 51.6 (1.2) | 50.1 (1.4) | 50.9 (1.4) | −1.55 (−3.99; 0.89) | 0.85 (−1.45; 3.15) | −0.71 (−3.58; 2.16) | ||||||||
| Social support & peers | 72.5 | 51.2 (1.0) | 50.2 (1.3) | 52.6 (1.5) | −0.94 (−3.49; 1.62) | 2.31 (−0.17; 4.80) | 1.38 (−1.30; 4.05) | ||||||||
| School environment | 69.4 | 51.8 (1.1) | 50.0 (1.5) | 51.0 (1.2) | −1.76 (−4.67; 1.15) | 0.99 (−1.58; 3.57) | 0.77 (−3.13; 1.59) | ||||||||
| Social acceptance and bullying | 70.0 | 40.9 (1.4) | 47.5 (1.4) | 47.0 (1.5) | 6.66 (3.96; 9.36) | −0.49 (−2.92; 1.95) | 6.17 (3.23; 9.11) | ||||||||
| PedsQL 4.0 | |||||||||||||||
| Overall | 71.9 | 67.8 (1.8) | 77.8 (1.6) | 77.8 (1.7) | 9.94 (6.66; 13.2) | 0.08 (−3.00; 3.16) | 10.0 (6.82; 13.2) | ||||||||
| Psychosocial health summary | 71.9 | 66.8 (2.0) | 75.6 (1.9) | 76.9 (2.0) | 8.79 (5.04; 12.5) | 1.30 (−1.83; 4.42) | 10.1 (6.49; 13.7) | ||||||||
| Physical health summary | 72.2 | 70.0 (1.8) | 81.9 (1.7) | 79.5 (2.2) | 11.9 (8.49; 15.2) | −2.34 (−6.73; 2.06) | 9.53 (5.10; 13.9) | ||||||||
| Physical functioning | 72.2 | 70.0 (1.8) | 81.9 (1.7) | 79.5 (2.2) | 11.9 (8.49; 15.2) | −2.34 (−6.73; 2.06) | 9.53 (5.10; 13.9) | ||||||||
| Emotional functioning | 72.2 | 65.8 (2.6) | 73.4 (2.7) | 75.2 (2.6) | 7.59 (2.69; 12.5) | 1.78 (−2.91; 6.48) | 9.37 (4.74; 14.0) | ||||||||
| Social functioning | 72.2 | 70.2 (2.4) | 82.3 (2.0) | 82.0 (2.2) | 12.1 (8.10; 16.2) | −0.28 (−3.63; 3.07) | 11.9 (7.83; 15.9) | ||||||||
| School functioning | 71.4 | 64.6 (2.1) | 70.9 (2.3) | 73.0 (2.5) | 6.32 (1.49; 11.1) | 2.13 (−2.15; 6.40) | 8.44 (3.81; 13.1) | ||||||||
| EuroQol | |||||||||||||||
| EQ-5D | 71.9 | 0.80 (0.02) | 0.89 (0.02) | 0.88 (0.02) | 0.09 (0.05; 0.13) | −0.01 (−0.06; 0.04) | 0.08 (0.03; 0.13) | ||||||||
| EQ-VAS | 71.9 | 69.0 (2.0) | 75.4 (1.6) | 70.7 (2.3) | 6.40 (2.35; 10.5) | −4.70 (−9.11; −0.29) | 1.70 (−2.67; 6.07) | ||||||||
| Weight-related HRQoL | |||||||||||||||
| IWQOL-Kids | |||||||||||||||
| Total | 65.8 | 70.8 (2.0) | 82.0 (1.9) | 79.7 (2.2) | 11.2 (7.37; 15.1) | −2.32 (−6.19; 1.56) | 8.92 (4.63; 13.2) | ||||||||
| Physical comfort | 70.6 | 70.4 (2.4) | 81.1 (2.4) | 76.8 (2.8) | 10.7 (7.17; 14.2) | –4.25 (–8.25; –0.26) | 6.44 (1.93; 11.0) | ||||||||
| Body esteem | 70.8 | 53.2 (2.7) | 70.8 (2.5) | 66.8 (3.0) | 17.6 (12.7; 22.6) | −3.99 (−9.73; 1.74) | 13.7 (7.78; 19.5) | ||||||||
| Social life | 68.9 | 74.5 (2.5) | 86.3 (2.1) | 87.0 (2.0) | 11.8 (7.09; 16.6) | 2.09 (−3.45; 4.78) | 12.5 (7.66; 17.4) | ||||||||
| Family relations | 68.8 | 90.8 (1.6) | 92.3 (1.9) | 91.1 (2.2) | 1.49 (−2.15; 5.13) | −1.25 (−4.93; 2.43) | 0.24 (−4.24; 4.73) | ||||||||
CI = Confidence interval; HRQoL = health-related quality of life; SE = standard error; ci = confidence interval.
Statistically significant values (p value < 0.05) are printed italics.
Total refers to 360 cases in the dataset (120 participants × 3 time points).
Generalized Linear Mixed Model with HRQoL score as dependent variable and time as independent variable, adjusted for adjusted for age, gender, ethnicity (Western, Non-Western), educational level of the parents/caregivers (low, medium/intermediate, high), SES (below average, above average), household situation (parents living together / parents not living together), and duration of inpatient treatment (2 months or 6 months).