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. Author manuscript; available in PMC: 2019 May 9.
Published in final edited form as: Cell Host Microbe. 2018 May 9;23(5):607–617.e6. doi: 10.1016/j.chom.2018.04.007

Figure 5. Cro augments mouse disease progression upon C. rodentium infection.

Figure 5

(A) Cartoon depicting the strategy utilized to exchange the EHEC ler promoter region to C. rodentium ler promoter region. The promoter was successfully exchanged using the λ recombination method, obtaining C.r-j11 and C.r-j11-pcro strains.

(B) Weight loss or gain from baseline (weight at day 0) over the course of infection (Blue: mock infected, Red: C. rodentium DBS100 wt, Purple: C. rodentium C.r-j11 pWSK129, and Green: C. rodentium C.r-j11-pcro) (n=10, error bars, standard deviation).

(C) Day 5 weight loss or gain statistical analysis comparing DBS100 against C.r-j11 pWSK129 and C.r-j11-pcro showing no statistical difference (NS).

(D) Day 6 weight loss or gain statistical analysis, comparing DBS100 against C.r-j11 pWSK129, and C.r-j11-pcro were depicting statistical difference at P<0.05.

(E) Day 7 weight loss or gain statistical analysis comparing DBS100 against C.r-j11pWSK129 and C.r-j11-pcro. The analysis shows statistical difference between DBS100 and C.r-j11-pcro (P<0.01), and no significance were observed comparing DBS100 and C.r-j11 pWSK129.

The nonparametric Mann-Whitney U test was used to determine the statistical significance using Graphpad prism software. See also Figure S6.