Fig. 2. (A) Neighbour joining tree constructed from a MUSCLE alignment including TTPRP primary sequences known to confer topoisomerase inhibitor resistance, (B) comparison of the Phyre-2 3D structure homology model of PcyT from Pyxidicoccus fallax to (C) the protein crystal structure of the topoisomerase targeting pentapeptide repeat protein (TTPRP) QnrB1 from K. pneumoniae.
