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. 2018 Jan 6;30(3):1437–1451. doi: 10.1007/s10811-017-1369-y

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — ML cladogram (− lnl = 3431.5512) for 165 LEGE CC strains having available data related to natural products. Capital letters in the tree highlight clades encompassing close-related strains for which the production of some of the following specific metabolites were detected (+) or not (−): Cyanotoxins: ANA-a anatoxin-a, BMAA β-Methylamino-L-alanine, CYN cylindrospermopsin, and MC microcystin. Bioactive compounds: 1 portoamides, 2 bartolosides, 3 dehydroabietic acid, 4 abietic acid, 5 hierridin B, and 6 anabaenopeptins A and D. Notice that the production (+) or absence of production (−) of the different compounds were confirmed by analytical techniques such as HPLC, LC-MS, or NMR. Metabolites between parentheses and symbols in gray indicate unpublished data. Symbols indicate the existence of data (either for the detection or non-detection) on: toxicity, bioactivity, or allelopathy assays (▲); screening of metabolites by MALDI-TOF Mass Spectrometry or by LC–MS analysis coupled with molecular networking [13] (■); cyanotoxins (•, first column); other than cyanotoxins nonribosomal peptide synthetases, polyketide synthases, or hybrid NRPS-PKS (•, second column); ribosomally synthesized and post-translationally modified peptides (Martins et al. 2013) (•, third column); and other family of compounds such as terpenes, glycolipids, etc. (•, fourth column). To get at the data on a particular strain, please find the literature references in the corresponding catalog sheet (Online Resource 3)

Fig. 4 — ML cladogram (− lnl = 3431.5512) for 165 LEGE CC strains having available data related to natural products. Capital letters in the tree highlight clades encompassing close-related strains for which the production of some of the following specific metabolites were detected (+) or not (−): Cyanotoxins: ANA-a anatoxin-a, BMAA β-Methylamino-L-alanine, CYN cylindrospermopsin, and MC microcystin. Bioactive compounds: 1 portoamides, 2 bartolosides, 3 dehydroabietic acid, 4 abietic acid, 5 hierridin B, and 6 anabaenopeptins A and D. Notice that the production (+) or absence of production (−) of the different compounds were confirmed by analytical techniques such as HPLC, LC-MS, or NMR. Metabolites between parentheses and symbols in gray indicate unpublished data. Symbols indicate the existence of data (either for the detection or non-detection) on: toxicity, bioactivity, or allelopathy assays (▲); screening of metabolites by MALDI-TOF Mass Spectrometry or by LC–MS analysis coupled with molecular networking [13] (■); cyanotoxins (•, first column); other than cyanotoxins nonribosomal peptide synthetases, polyketide synthases, or hybrid NRPS-PKS (•, second column); ribosomally synthesized and post-translationally modified peptides (Martins et al. 2013) (•, third column); and other family of compounds such as terpenes, glycolipids, etc. (•, fourth column). To get at the data on a particular strain, please find the literature references in the corresponding catalog sheet (Online Resource 3)