Table 4.

Clusters of significant (p_FWE < 0.05) correlation between DTI measures and MRS metabolites as identified by tract-based spatial statistics (TBSS) with threshold-free cluster enhancement (TFCE).

	MNI Coordinates			Cluster size	t	pFWE
	X	Y	Z
Control
Negative correlation: RD in the cingulum – Hippocampal NAA/Cr
	−25	−20	−24	43	4.42	0.016
	−32	−25	−25		3.96
	−29	−22	−24		3.86
Negative correlation: AD in the cingulum – Hippocampal NAA/Cr
	−29	−29	−17	76	4.66	0.020
	−25	−20	−24		3.89
	−25	−26	−19		3.86
	−30	−24	−23		3.73
	−26	−23	−23		3.73
	−32	−25	−23		3.27
Negative correlation: FA in the cingulum – ACC Glx/Cr
	−24	−27	−18	44	4.38	0.022
	−24	−25	−18		4.25
	−30	−26	−20		3.61
Schizophrenia	–	–	–	–	–	ns