Table 3.

The top 15 hub proteins identified in topological analysis of the PPI network of the SARGs and OMRGs.

DEGs	Degree	Betweenness centrality	Closeness centrality	Gene name	Expression change
SARGs	38	0.26824799	0.47773279	IL8	Down
	27	0.17520903	0.4469697	IL4	Down
	25	0.2014464	0.45559846	MPO	Up
	19	0.10405493	0.43382353	ELANE	Up
	19	0.13489376	0.3973064	CAMP	Up
	17	0.07247173	0.41403509	MMP9	Up
	15	0.03397526	0.39464883	CTSG	Up
	15	0.08304961	0.41403509	SLC11A1	Up
	14	0.11008923	0.34911243	LCK	Down
	14	0.04295219	0.35014837	DEFA4	Up
	12	0.01906122	0.38688525	SELP	Up
	12	0.01119682	0.37820513	CEACAM8	Up
	11	0.0757675	0.37341772	MAPK14	Up
	11	0.03156578	0.36990596	IL7	Down
	11	0.00741906	0.37699681	AZU1	Up
OMRGs	33	0.34532099	0.37587007	PHLPP2	Down
	23	0.28324927	0.36986301	EGF	Up
	16	0.14451349	0.36	PIKFYVE	Down
	15	0.19939732	0.38297872	HSPA8	Down
	13	0.06895809	0.30975143	HIST2H2BE	Up
	13	0.09823181	0.3375	UBE2D1	Up
	12	0.12053919	0.30740038	CD79A	Down
	11	0.0633676	0.31702544	ERBB2	Down
	11	0.04845481	0.29944547	CD86	Down
	10	0.08593619	0.33128834	MPP6	Down
	10	0.10468113	0.3246493	PCSK6	Up
	9	0.07043681	0.29294756	VWF	Up
	9	0.06127452	0.31764706	GNAO1	Up
	9	0.08899187	0.33264887	TLR2	Up
	8	0.00375522	0.26821192	HIST2H2AC	Up