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. 2017 Dec 13;33(6):923–934. doi: 10.1093/ndt/gfx304

FIGURE 4.

FIGURE 4

Serum creatinine and ADMA levels 4 and 8 weeks after surgically induced CKD in GPx3−/− from nonserial blood draws. (A) Serum creatinine (mg/dL) at 4 weeks WT + sham (0.11 ± 0.02) (n = 6) versus WT + CKD (0.21 ± 0.02) (n = 6) (*P < 0.001) and 8 weeks 0.11 ± 0.02 (n = 6) versus 0.20 ± 0.02 (n = 6) (**P < 0.001), respectively; GPx3−/− + sham (0.13 ± 0.02) (n = 6) versus GPx3−/− + CKD (0.22 ± 0.02) (n = 6) (†P < 0.001) and 8 weeks [0.12 ± 0.02 (n = 6) versus 0.21 ± 0.02 (n = 6)] (‡P < 0.001), respectively. (B) Serum ADMA (μM) at 4 weeks WT + sham (0.47 ± 0.47) (n = 4) versus WT + CKD (5.00 ± 0.80) (n = 4) (*P < 0.001) and GPx3−/− + sham (0.39 ± 0.39) (n = 6) versus GPx3−/− + CKD (7.08 ± 0.66) (n = 7) (**P = 0.019) and 8 weeks WT + sham [0.39 ± 0.38 (n = 6)] versus WT + CKD [5.40 ± 4.07 (n = 7)] (†P = 0.030) and GPx3−/− + sham [0.59 ± 0.57 (n = 6)] versus GPx3−/− + CKD [5.34 ± 4.04 (n = 7)] (‡P = 0.024), respectively. (C) Plasma L-arginine (μM) at 4 weeks WT + sham (44 ± 16) (n = 4) versus WT + CKD (41 ± 30) (n = 5) (P = NS) and GPx3−/− + sham (41 ± 19) (n = 4) versus GPx3−/− + CKD (51 ± 30) (n = 4)] (P = NS) and 8 weeks WT + sham [38 ± 13 (n = 4)] versus WT + CKD [23 ± 10 (n = 5)] (P = NS) and GPx3−/− + sham [35 ± 17 (n = 4)] versus GPx3−/− + CKD [21 ± 8 (n = 4)] (P = NS), respectively.