Table 4.
Association Between Maternal Psychosocial Stress 6 Months After Delivery and Offspring Asthma at Age 7 Years as Defined by the Norwegian Prescription Database, Norwegian Mother and Child Cohort Study, 2000–2007
| Measure of Maternal Psychosocial Stress 6 Months After Delivery | Range of Scale Scores | No. of Children | No. of Cases | Median (IQR) | Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Model 1a | Model 2b | |||||||||
| RR | 95% CI | RR | 95% CI | RR | 95% CI | |||||
| SCL-5 scorec | 1–4 | 63,332 | 2,649 | 1.0 (1.0–1.4) | 1.30 | 1.19, 1.41 | 1.17 | 1.07, 1.28 | 1.09 | 0.98, 1.21 |
| Satisfaction With Life Scaled | 1–7 | 62,844 | 2,626 | 6.0 (5.4–6.4) | 0.92 | 0.89, 0.95 | 0.96 | 0.93, 1.00 | 0.96 | 0.91, 1.00 |
| Relationship satisfactiond | 1–6 | 61,679 | 2,553 | 5.4 (5.0–5.8) | 0.96 | 0.91, 1.01 | 1.00 | 0.95, 1.06 | 1.00 | 0.93, 1.08 |
| Negative life events after 30 weeks’ gestationc | 0–10 | 63,626 | 2,659 | 0.0 (0.0–1.0) | 1.20 | 1.17, 1.24 | 1.14 | 1.11, 1.18 | 1.12 | 1.09, 1.16 |
| Use of antidepressants, anxiolytics, and/or hypnotics during pregnancy | ||||||||||
| No | 62,860 | 2,621 | N/A | 1.00 | Referent | 1.00 | Referent | 1.00 | Referent | |
| Yes | 766 | 38 | N/A | 1.19 | 0.87, 1.63 | 1.01 | 0.73, 1.41 | 0.95 | 0.67, 1.34 | |
Abbreviations: CI, confidence interval; IQR, interquartile range; N/A, not applicable; RR, relative risk; SCL-5, 5-item symptom checklist.
a Model 1 adjusted for maternal age, parity, education, smoking during pregnancy, prepregnancy body mass index, smoking during the first 6 months of the child’s life, and history of asthma, in addition to child’s sex, birth weight, gestational age, and breastfeeding during the first 6 months of life.
b Model 2 adjusted for the characteristics described for model 1 and for maternal report of the same measure of psychosocial stress during pregnancy.
c Higher scores indicates more stress.
d Higher scores indicates less stress.